Twenty years of ageing research at the Mill Hill laboratories

Experimental Gerontology

Volumn 37, Issue 7, 2002, Pages 851-857

  Holliday, Robin ^a,b  

^a Royal Society   (United Kingdom)

^b NONE   (Australia)

Author keywords

Accuracy; Ageing; DNA; Evolution; Fibroblasts; Gerontology; Mutations; Proteins

Indexed keywords

ACCURACY; AGING; ANIMAL CELL; CELL GROWTH; CELL TRANSFORMATION; DIPLOIDY; DNA REPLICATION; DNA SYNTHESIS; EVOLUTION; FIBROBLAST; HUMAN; HUMAN CELL; LYMPHOCYTE; MEDICAL RESEARCH; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PUBLICATION; REVIEW; SENESCENCE; SPECIES DIFFERENCE; UNITED KINGDOM;

ANIMALIA;

EID: 0036082652     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(02)00030-X     Document Type: Article

References (51)

1. Telomere length predicts replicative capacity of human fibroblasts
2. Fidelity of histone synthesis in cultured human fibroblasts
3. Limited lifespan in somatic cell hybrids and cybrids
4. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
5. UK research on the biology of aging
6. The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine induced demethylation
7. Spontaneous mutations and ageing of human cells in culture
8. A rapid rise in cell variants during the senescence of populations of diplod fibroblasts
9. The limited in vitro lifetime of human diploid cell strains
10. Errors in protein synthesis and clonal senescence in fungi
11. Towards a biological understanding of the ageing process
12. The current status of the protein error theory of aging
13. Predictions of the somatic mutation and mortalisation theories of cellular ageing are contrary to experimental observations
14. Evidence that paromomycin induces premature ageing in human fibrobalsts
15. Altered enzymes in ageing human fibroblasts
16. Premature ageing and occurrence of altered enzyme in Werner's syndrome fibroblasts
17. Testing the commitment of cellular ageing
18. Further evidence for the commitment theory of cellular ageing
19. Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specifity
20. The limited and unlimited growth of SV40 transformed from human diploid MRC-5 fibroblasts
21. The susceptibility of Werner's syndrome and other human skin fibroblasts to SV40-induced transformation and immortalisation
22. Characteristics of a human diploid cell designated MRC-5
23. Evolution of ageing
24. The evolution of ageing and longevity
25. Commitment to senescence: A model for the finite and infinite growth of diploid and transformed human fibroblasts in culture
26. Stability of the translation process
27. Mistranslation and ageing in Neurospora
28. Decreased fidelity of DNA polymerase activity isolated from ageing human fibroblasts
29. Maintenance of DNA methylation level in SV40 infected human fibroblasts during their in vitro limited proliferative lifespan
30. Use of H1 histone to test the fidelity of protein synthesis in mouse tissues
31. Age changes in chromatin: Accumulative or programmed?
32. Human lymphocytes resistant to 6-thioguanine increase with age
33. Increased error frequency of DNA polymerases from senescent human fibroblasts
34. Kinetic amplification of enzyme discrimination
35. The maintenance of the accuracy of protein synthesis and its relevance to ageing
36. The maintenance of the accuracy of protein synthesis and its relevance to ageing: A correction
37. Ageing of clones of mammalian cells
38. Altered rate of DNA replication in ageing human fibroblast cultures
39. Autofluorescence as an index of ageing in human fibroblasts in culture
40. Steptomycin-induced protein error propagation appears to lead to cell death in Escherichia coli
41. Senescence and the accumulation of abnormal proteins
42. Mechanisms responsible for the limited lifespan and immortal phenotypes in cultured mammalian cells
43. Aneuploidy in the degenerative phase of the serial cultivation of human cell strains
44. Increased degradation rates of protein in ageing human fibroblasts, and in cells treated with an amino acid analogue
45. Effect of temperature on the longevity of human fibroblasts
46. Chromosome exchanges during the in vitro ageing of MRC-5 human fibroblasts
47. The longevity of diploid and polyploid human fibroblasts: Evidence against the somatic mutation theory of ageing
48. Genetic effects on the longevity of cultured human fibroblasts. 1. Werner's syndrome
49. DNA methylation decreases in ageing but not in immortal cells