Hyperosmotic mannitol activates basolateral NHE in proximal tubule from P-glycoprotein null mice

American Journal of Physiology - Renal Physiology

Volumn 282, Issue 4 51-4, 2002, Pages

  Miyata, Yukio ^a   Asano, Yasushi ^a   Muto, Shigeaki ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Intracellular pH measurement; Isolated nonperfused tubule; Regulatory volume increase; Sodium hydrogen exchange

Indexed keywords

2',7' BIS(CARBOXYETHYL) 5(6) CARBOXYFLUORESCEIN ACETOXYMETHYL ESTER; ACID; CALPHOSTIN C; FLUORESCENT DYE; GENE PRODUCT; GLYCOPROTEIN P; MANNITOL; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN MDR1A; PROTEIN MDR1B; SODIUM ION; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HYPEROSMOLALITY; KIDNEY PROXIMAL TUBULE; MALE; MICHAELIS CONSTANT; NONHUMAN; PH; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; VELOCITY;

EID: 0036080666     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00183.2001     Document Type: Article

References (32)

1. + exchanger in renal microvillus membrane vesicles
2. Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange
3. -
4. Basolateral Na-H exchange in the rabbit cortical collecting tubule
5. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissue
6. Regulation of renal tubule cell volume in hypotonic media
7. Expression of MDR1 (multidrug resistance) gene and its protein in normal human kidney
8. + exchange in human endothelial cells
9. Cell volume regulation in the proximal convoluted tubule
10. Basolateral sodium-coupled acid-base transport mechanisms of the rabbit proximal tubule
11. Biochemistry of multidrug resistance mediated by multidrug transporter
12. + exchange pathway; reversibility of transport and asymmetry of the modifier site
13. + exchange in rat thymic lymphocytes
14. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
15. + antiport in the renal proximal tubule cell
16. -/base exchange in the rabbit S3 proximal tubule
17. Functional significance of cell volume regulatory mechanisms
18. Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells
19. Isovolumetric regulation of isolated S2 proximal tubules in anisosmotic media
20. Calcium signaling in cell volume regulation
21. Effects of P-glycoprotein on cell volume regulation in mouse proximal tubule
22. + exchanger in rat mesangial cells
23. P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule
24. Interaction of lithium and protons with the sodiumproton exchanger of dog red blood cells
25. Intracellular pH
26. Proton pathways in rat renal brush-border and basolateral membranes
27. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
28. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
29. Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells
30. Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues
31. P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro
32. Hyperosmolality induced activation of cPKC and nPKC, a requirement for ERK1/2 activation in NIH/3T3 cells