A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1560-1566

  Serrador, Juan M ^a   Urzainqui, Ana ^a   Alonso Lebrero, Jose L ^a   Cabrero, J Román ^a   Montoya, Maria C ^a   Vicente Manzanares, Miguel ^a   Yáñez Mó, María ^a   Sánchez Madrid, Francisco ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cell migration; Cytoskeleton; Lymphocyte; Polarization; Uropod

Indexed keywords

ALANINE; AMINO ACID; CHEMOKINE; EZRIN; MEMBRANE PROTEIN; MOESIN; P SELECTIN GLYCOPROTEIN LIGAND 1; RADIXIN; RECEPTOR PROTEIN; SERINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; LYMPHOCYTE MIGRATION; LYMPHOID CELL; MICROSCOPY; MICROVILLUS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; BLOOD PROTEINS; CELL MEMBRANE; CELL MOVEMENT; CYTOSKELETAL PROTEINS; HUMANS; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; RATS;

EID: 0036080407     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1560::AID-IMMU1560>3.0.CO;2-U     Document Type: Article

References (27)

1. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
2. Role of PSGL-1 binding to selectins in leukocyte recruitment
3. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin
4. Microspikes on the lymphocyte uropod
5. Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces
6. Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells
7. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts
8. Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins
9. Ezrin/radixin/moesin (ERM) protein bind to a positively charged amino acid cluster in the juxtamembrane cytoplasmic domain of CD44, CD43, and ICAM-2
10. Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2)
11. The cytoplasmic tail of L-selectin interacts with members of the ezrin-radixin-moesin (ERM) family of proteins: Activation dependent binding of moesin but not ezrin
12. Expression cloning of a functional glycoprotein ligand for P-selectin
13. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
14. Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane
15. Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues
16. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
17. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells bind to P-selectin and supports migration into inflamed skin
18. P-selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration
19. Direct observation of membrane tethers formed during neutrophil attachment to platelets or P-selectin under physiological flow
20. Dimerization of a selectin ligand stabilizes cell rolling and enhances tether strength in shear flow
21. P-selectin glycoprotein ligand-1is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells
22. ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes
23. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow
24. ERM-dependent movement of CD43 defines a novel Protein complex distal to the immunological synapse
25. Role of ICAM-3 in the initial interaction of T lymphocytes and antigen presenting cells
26. Disruption of dynamic cell surface architecture of NIH3T3 fibroblasts by the N-terminal domains of moesin and ezrin: In vivo imaging with GFP fusion proteins
27. Replacement of 558 threonine, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin: Regulation by conformational change