Pathogenic mechanism of type 2 diabetes in Ghanaians - The importance of beta cell secretion, insulin sensitivity and glucose effectiveness

South African Medical Journal

Volumn 92, Issue 5, 2002, Pages 377-384

  Amoah, Albert G B ^a   Owusu, Samuel K ^a   Schuster, Dara P ^a   Osei, Kwame ^a  

^a UNIVERSITY OF GHANA   (Ghana)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLIBENCLAMIDE; GLUCOSE; INSULIN; METFORMIN; SULFONYLUREA;

ADULT; ANTHROPOMETRY; ARTICLE; BICEPS BRACHII MUSCLE; BODY FAT; BODY MASS; CELL SECRETION; CLINICAL ARTICLE; CONTROLLED STUDY; DETERIORATION; DIET RESTRICTION; FAMILY HISTORY; FEMALE; GHANA; GLUCOSE INTOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LEAN BODY WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PATHOGENESIS; POSTPRANDIAL STATE; PROSPECTIVE STUDY; RELATIVE; SKINFOLD THICKNESS; TRICEPS BRACHII MUSCLE;

ADULT; ANTHROPOMETRY; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GHANA; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE;

EID: 0036079663     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults
2. Global burden of diabetes. 1995-2025. Prevalence and numerical estimates and projections
3. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in US population aged 20-74
4. Prevalence of diabetes and glucose intolerance in 199 offspring of 37 conjugal parents
5. Diabetes in identical twins. A study of 200 pairs
6. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose uptake
7. Nonketotic diabetes mellitus: Insulin deficiency or insulin resistance
8. Relationship between glucose tolerance, insulin secretion, and insulin action in obese individuals with varying degrees of glucose tolerance
9. Sequential changes in serum insulin concentration during development of non-insulin-dependent diabetes
10. Evidence for impaired pancreatic beta cell function in southern African Indians with impaired glucose tolerance
11. Loss of the first phase response to intravenous glucose in subjects with persistent impaired glucose tolerance
12. In vivo insulin action is a familial characteristic in non-diabetic Pima Indians
13. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a follow-up study
14. Beta cell dysfunction rather than insulin sensitivity is the primary defect in familial type 2 diabetes
15. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin dependent mellitus
16. Familial clustering of insulin sensitivity
17. Insulin sensitivities and insulin insensitive variants of NIDDM
18. Diabetes in Ghana
19. Diabetes in Ghana. A morbidity and mortality analysis
20. Diabetes in Africa
21. Ethnic differences in secretion, sensitivity and hepatic extraction of insulin in black and white Americans
22. Early metabolic defects in persons at risk for noninsulin-dependent diabetes mellitus
23. Increased insulin concentrations in non-diabetic offspring of diabetic patients
24. Glucose and serum insulin responses to intravenous glucose challenge in relatives of Nigerian patients with noninsulin-dependent diabetes mellitus
25. Lean body mass estimation by bioelectrical impedance analysis; a four-site cross-validation study
26. Toward physiological understanding of glucose tolerance: Minimal model approach
27. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
28. The contribution of insulin-dependent and insulin independent glucose uptake to intravenous glucose tolerance in healthy human subjects
29. Prevalence of NIDDM among populations of African Diaspora
30. Prevalence of NIDDM and impaired glucose tolerance in rural and urban populations in Cameroon
31. Reduced insulin secretion in offspring of African type 2 diabetic patients
32. Metabolic characteristics of African descendants: A comparative study of African-Americans and Ghanaian immigrants using minimal model analysis
33. Minimal model analyses of insulin sensitivity and glucose dependent glucose disposal in black and white Americans: A study of persons at risk for type 2 diabetes
34. Pathogenetic mechanism of impaired glucose tolerance and type II diabetes in African Americans. The significance of insulin secretion, insulin sensitivity and glucose effectiveness
35. Decreased insulin-mediated but not non-insulin dependent glucose disposal in glucose intolerance and type 2 diabetes in African (Ghanaian) immigrants
36. Insulin sensitivity and acute insulin responses in African Americans, non-Hispanic whites and Hispanics and NIDDM: The Insulin Resistance and Atherosclerosis Study
37. Increased insulin resistance and insulin secretion in non-diabetic African Americans and Hispanics compared with non-Hispanic whites
38. Ethnic differences in fasting plasma c-peptide and insulin in relation to glucose tolerance and blood pressure
39. Features of insulin resistance syndrome in men from French Caribbean Islands
40. Unexplained hyperinsulinemia in normal and prediabetic Pima Indians when compared with normal Caucasians. An example of racial differences in insulin secretion
41. Metabolic abnormalities in children of noninsulin-dependent patients
42. Insensitivity of insulin in offspring of noninsulin-dependent diabetic patients
43. Insulin sensitivity and insulin secretion in subjects with impaired glucose tolerance: A minimal model analysis
44. Pathogenic factors responsible for future glucose tolerance in patients with NIDDM