Family of hemorphins: Co-relations between amino acid sequences and effects in cell cultures

Peptides

Volumn 23, Issue 5, 2002, Pages 903-910

  Blishchenko, Elena Y ^a   Sazonova, Olga V ^a   Kalinina, Olga A ^a   Yatskin, Oleg N ^a   Philippova, Marina M ^a   Surovoy, Andrei Y ^a   Karelin, Andrei A ^a   Ivanov, Vadim T ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Cytotoxicity; Hemorphin; Proliferation

Indexed keywords

GLUTAMINE; HEMORPHIN 4; HEMORPHIN 5; LEUCINE; LEUCYLVALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMINE; LEUCYLVALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMINYLARGINYLTYROSINE; LEUCYLVALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMYLARGININE; LEUCYLVALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMYLARGINYLPHENYLALANINE; METENKEPHALIN; POLYPEPTIDE; SPINORPHIN; TYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMYLARGINYLPHENYLALANINE; UNCLASSIFIED DRUG; VALYLTYROSYLPROLYLTRYPTOPHYLTHREOLYLGLUTAMYLARGINYLPHENYLALANINE; VALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONINE; VALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMINE; VALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMYLARGININE; VALYLVALYLTYROSYLPROLYLTRYPTOPHYLTHREONYLGLUTAMYLARGINYLPHENYLALANINE; HEMOGLOBIN; LVV HEMORPHIN 6; LVV-HEMORPHIN 6; PEPTIDE FRAGMENT; VV HEMORPHIN 7; VV-HEMORPHIN-7;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; FIBROBLAST; GROWTH INHIBITION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY;

MURINAE;

AMINO ACID SEQUENCE; ANIMALS; HEMOGLOBINS; MICE; PEPTIDE FRAGMENTS; TUMOR CELLS, CULTURED;

EID: 0036078101     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00017-7     Document Type: Article

References (50)

1. High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the beta-chain of hemoglobin
2. Endogenous fragment of hemoglobin, neokyotorphin, as cell growth factor
3. Tubocurarin induces the wide spectrum of cytolytic effects in tumor cells
4. Biological activity of the components of tissue specific peptide pools in cell culture
5. Tumor cell cytolysis mediated by valorphin an opioid-like fragment of hemoglobin beta-chain
6. Neokyotorphin and neokyotorphin (1-4): Secretion by erythrocytes and regulation of tumor cell growth
7. Novel opioid peptides derived from hemoglobin: Hemorphins
8. Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture
9. Enhancement of the generation of cytotoxic T cells by endogenous opiates
10. Isolation and structure of several peptides from porcine hypothalami
11. Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo
12. Isolation of the opioid peptide Leu-Val-Val-hemorphin-7 from bronchoalveolar lavage fluid of a patient with non-small cell lung cancer
13. Isolation of a heptapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln (valorphin) with some opiate activity
14. Structure of two myelopeptides affecting pain sensitivity
15. VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides
16. Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland
17. Concomitant increase in blood plasma levels of immunoreactive hemorphin-7 and beta-endorphin following long distance running
18. Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings
19. The antiproliferative effect of opioid receptor agonists on the T74D breast cancer cell line, is partially mediated through opioid receptors
20. Antiproliferative and receptor binding properties of alpha- and beta-casomorphins in the T47D human breast cancer cell line
21. Somatostatin opioid receptors in mammary tissue. Role in cancer cell growth
22. Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes
23. Proteolytic degradation of hemoglobin in vivo. Role in formation of tissue-specific peptide pool
24. Hemoglobin as a source of endogenous bioactive peptides: The concept of tissue-specific peptide pool
25. Tissue-specific peptide pools. Generation and function
26. Enhancement of tumor growth by morphine and its possible mechanism in mice
27. Effects of steroid hormones and opioid peptides on the growth of androgen-responsive Shionogi carcinoma (SC115) cells in primary culture
28. Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors
29. Isolation of endogenous hemorphin-related hemoglobin fragments from bovine brain
30. Peptides comprising the bulk of rat brain extracts: Isolation, amino acid sequences and biologecal activity
31. Differential effects of methionine enkephalin on the growth of brain tumor cells
32. Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin
33. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines
34. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells
35. Regulation of DNA synthesis of myocardial and epicardial cells in developing rat heart by [Met5]enkephalin
36. Met-enkephalin induces cytolytic processes of apoptotic type in K562 human erythroid leukemia cells
37. Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord
38. Morphine effect on proliferation of normal and tumor cells of immune origin
39. Myelopeptide (Bivalfor) exhibits an antitumor effect
40. Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines
41. Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes
42. LVV- and VV-hemorphins: Comparative levels in rat tissues
43. Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments and two potent analogs
44. Binding of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) and related peptides to mu 1 and mu 2 opiate receptors
45. Endogenous opioid systems and neural cancer: Transmission and scanning electron microscopic studies of murine neuroblastoma in tissue culture
46. Opioid growth factor tonically inhibits human colon cancer proliferation in tissue culture
47. Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice
48. Endogenous opioid systems regulate growth of neural tumor cells in culture
49. Peptic hemoglobin hydrolysis in an ultrafiltration reactor at pilot plant scale generates opioid peptides