Studies on the cardiotoxicity of noradrenaline in isolated rabbit hearts

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 7, 2002, Pages 543-551

  Rump, Alexis F E ^a   Schierholz, Jörg ^a   Klaus, Wolfgang ^a  

^a Schiffahrtmedizinisches Institut der Marine   (Germany)

Author keywords

CAS 51 41 2; Catecholamines, cardiotoxicity; Myocardial ischemia; Noradrenaline, cardiotoxicity; Oxygen free radicals; Superoxide dismutase

Indexed keywords

NORADRENALIN; OXYGEN RADICAL; PHENTOLAMINE; PROPRANOLOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RESERPINE; SUPEROXIDE DISMUTASE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CARDIOTOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY LIGATION; DRUG EFFECT; DRUG MECHANISM; FLUORESCENCE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; NONHUMAN; RABBIT;

EID: 0036073962     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299928     Document Type: Article

References (45)

1. Free radicals, antioxidants, and human disease: Where are we now?
2. GSH-dependent inhibition of lipid peroxidation: Properties of a potent cytosolic system which protects cell membranes
3. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence?
4. Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischaemia and reperfusion injury, and in cerebral vascular damage
5. Free radicals as mediators of tissue injury and disease
6. Oxidative stress in clinical situations - Fact or fiction?
7. Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues
8. Free radicals and myocardial injury: Pharmacologic implications
9. Ischemia-reperfusion injury: Role of oxygen-derived free radicals
10. Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischaemic and reperfused isolated hearts
11. Evidence for a reversible oxygen radical mediated component of reperfusion injury: Reduction by recombinant human superoxide dismutase administered at the time of reflow
12. Human superoxide dismutase failed to limit the size of myocardial infarct after 20-, 30-, or 60 minute ischemia and 72-hour reperfusion in the rabbit
13. Superoxide dismutase: Possible therapeutic use in cardiovascular disease
14. Reduction of the extent of ischaemic myocardial injury by neutrophil depletion in the dog
15. Mitochondrial production of superoxide anion and ist relationship to the antimicyn-insensitive respiration
16. Biology of disease. Free radicals and tissue injury
17. Cardiotoxicity of catecholamines and related agents
18. Cardioprotection by superoxide dismutase: A catecholamine-dependent process?
19. Propranolol inhibits nonexocytotic noradrenaline release in myocardial ischemia
20. Evidence for norepinephrine cardiotoxicity mediated by superoxide anion radicals
21. Untersuchungen am überlebenden säugetierherzen
22. Epicardial image analysis using desk-top computer - Comparison of epicardial flow distribution and NADH-fluorescence pattern
23. Studies of the cardioprotective effects of ascorbic acid in isolated rabbit hearts
24. Mathematical analysis of concentration-response relationships
25. Evaluation of cardiac ischemia by NADH fluorescence photography
26. The influence of nifedipine on three dimensional distribution of ATP in regional ischemic rabbit hearts
27. Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts
28. Validity of myocardial oxygen consumption parameters
29. Species variation in the coronary collateral circulation during regional myocardial ischaemia: A critical determinant of the rate of evolution and extent of myocardial infarction
30. Comparison of the cardioprotective efficacy of superoxide dismutase in a single and a repetitive coronary occlusion model
31. A quantitative comparison of functional and antiischemic effects of phosphodiesterase-inhibitors amrinone, milrinone and levosimendan in isolated rabbit hearts
32. Ischaemic preconditioning: From mechanisms to exploitation
33. Cardioprotection from ischemic preconditioning is lost following prolonged reperfusion in rabbits
34. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat
35. Studies on infarct-like myocardial necrosis produced by isoproterenol: A review
36. Toxicity of aminochromes
37. Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH-fluorescence
38. Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release
39. Neuronal sodium homeostasis and axoplasmic amine concentrations determine calcium-independent noradrenaline release in normoxic and ischemic rat heart
40. Cardiac sympathetic activity in myocardial ischemia: Release and effects of noradrenaline
41. Oxygen free radicals and myocardial damage: Protective role of thiol-containing agents
42. Mechanisms of cardiovascular drugs as antioxidants
43. Protection by beta-blocking agents against free radical-mediated sarcolemmal lipid peroxidation