Quick, simple, and sensitive HPLC method for determination of isradipine in plasma and its application in pharmacokinetic studies

Analytical Letters

Volumn 35, Issue 7, 2002, Pages 1205-1213

  Al Suwayeh, Saleh A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Assay validation; HPLC analysis; Isradipine; IV administration; Pharmacokinetics

Indexed keywords

DIAZEPAM; ISRADIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RABBIT; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

EID: 0036073827     PISSN: 00032719     EISSN: None     Source Type: Journal    
DOI: 10.1081/AL-120005973     Document Type: Article

References (8)

1. Cardiac function improvement 24 hours after isradipine SRO in patients with chronic stable angina
2. Felodipine and isradipine: New agents for the treatment of hypertension
3. Assay of isradipine and of its major metabolites in biological fluids by capillary gas chromatography and chemical ionization mass spectrometry
4. Pharmacokinetics of PN200-110 (isradipine), a new calcium antagonist, after oral administration in man
5. Isocratic high-performance liquid chromatographic method for the separation of isradipine and its main metabolites, application to in vitro metabolization by h3A4/OR cells
6. Determination of isradipine and the oxidative pyridine metabolite in human plasma by high-performance liquid chromatography