A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes

Molecular and Biochemical Parasitology

Volumn 122, Issue 1, 2002, Pages 21-33

  Britton, Collette ^a   Murray, Linda ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Caenorhabditis elegans; Cathepsin L; Cysteine protease; Nematode; Parasite; RNAi rescue

Indexed keywords

CATHEPSIN; PROTEINASE;

AMINO ACID SEQUENCE; ANCYLOSTOMA CANINUM; ARTICLE; ASCARIS SUUM; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CPL 1 GENE; DICTYOCAULUS VIVIPARUS; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENE STRUCTURE; HAEMONCHUS CONTORTUS; LETHALITY; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PRIORITY JOURNAL; TELADORSAGIA CIRCUMCINCTA;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATHEPSINS; CONSERVED SEQUENCE; CYSTEINE ENDOPEPTIDASES; GENES, HELMINTH; GENETIC COMPLEMENTATION TEST; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEMATODA; PHENOTYPE; PHYLOGENY; RNA, DOUBLE-STRANDED; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

ANCYLOSTOMA; ANCYLOSTOMA CANINUM; ANIMALIA; ASCARIS SUUM; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DICTYOCAULUS; DICTYOCAULUS VIVIPARUS; HAEMONCHUS CONTORTUS; NEMATODA; TELADORSAGIA; TELADORSAGIA CIRCUMCINCTA; VIVIPARUS;

EID: 0036072851     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00066-X     Document Type: Article

References (45)

1. Alignment/phylogeny of the papain superfamily of cysteine proteases
2. Plasma membrane associated cysteine proteases in human and animal tumours
3. Ability of activated complement components to induce lysosomal enzyme release from macrophages
4. In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption
5. Parasite proteases
6. The lysosomal cysteine proteases
7. Molecular cloning and primary sequence of a cysteine protease expressed by Haemonchus contortus adult worms
8. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae
9. Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles
10. Proteinases and associated genes of parasitic helminths
11. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans
12. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
13. The C. elegans sequencing consortium genome sequence of the nematode C. elegans: A platform for investigating biology
14. 200 000 nematode expressed sequence tags on the Net
15. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans
16. Molecular cloning and characterization of gut-derived cysteine proteinases associated with a host protective extract from Haemonchus contortus
17. Cloning and sequence comparisons of four distinct cysteine proteases expressed by Haemonchus contortus adult worms
18. Isolation of putative cysteine protease genes of Ostertagia ostertagi
19. Characterization and localization of cathepsin B proteinases expressed by adult Ancylostoma caninum hookworms
20. Developmentally regulated secretion of cathepsin L-like cysteine proteases by Haemonchus contortus
21. Structural analysis of the catalytic site of AcCP-1, a cysteine proteinase secreted by the hookworm Ancylostoma caninum
22. Characterization of two cDNAs encoding cysteine proteinases from the soybean cyst nematode Heterodera glycines
23. Identification of prokaryotic and eukaryotic signal peptides and reduction of their cleavage sites
24. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence
25. Basic local alignment search tool
26. Methods
27. Efficient gene-transfer in C. elegans - Extrachromosomal maintenance and integration of transforming sequences
28. Temporal reiteration of a precise gene expression pattern during nematode development
29. Host movement and the genetic structure of populations of parasitic nematodes
30. Cloning, genomic organization and chromosomal localization of human cathepsin L
31. Organization and expression of eukaryotic split genes coding for proteins
32. Isolation and sequence of a cDNA for human pro-cathepsin L
33. Molecular cloning and sequencing of cDNA that encodes cysteine proteinase in the eggs of the silkmoth, Bombyx mori
34. Autocatalytic processing of recombinant human cathepsin L
35. Two distinct gene subfamilies within the family of cysteine protease genes
36. Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae
37. A molecular evolutionary framework for the phyum Nematoda
38. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
39. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
40. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
41. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway
42. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
43. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
44. Compartive molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources