Absolute bioavailability and stereoselective pharmacokinetics of doxepin

Xenobiotica

Volumn 32, Issue 7, 2002, Pages 615-623

  Yan, J H ^a   Hubbard, J W ^a   McKay, G ^a   Korchinski, E D ^b   Midha, K K ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOXEPIN; NORDOXEPIN;

ADULT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; ISOMERISM; KIDNEY CLEARANCE; MALE; NORMAL HUMAN; PLASMA; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ADULT; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DOXEPIN; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; STEREOISOMERISM;

EID: 0036068980     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250210131879     Document Type: Article

References (26)

1. Quantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography
2. A new look at the statistical model identification
3. Plasma levels of the cis- and trans-isomers of doxepin and desmethyldoxepin after administration of doxepin to patients
4. High-performance liquid chromatographic determination of trans-doxepin and desmethyldoxepin
5. Multiple-dose doxepin kinetics in depressed patients
6. Relationship of blood levels of Sinequan to clinical effects in the treatment of depression in aged patients
7. Geometric isomerization of doxepin during its N-demethylation in humans
8. Influence of first pass effect on availability of drugs on oral administration
9. Clinical importance of doxepin plasma levels
10. Distribution and metabolism of doxepin
11. Cis- and trans-isomers of doxepin and desmethyldoxepin in the plasma of depressed patients treated with doxepin
12. Doxepin hydrochloride: Absorption, distribution, excretion and metabolism of doxepin
13. The quaternary ammonium-linked glucuronide of doxepin: A major metabolite in depressed patients treated with doxepin
14. Stereoselective pharmacokinetics of doxepin isomers
15. Doxepin up-to-date: A review of its pharmacological properties and therapeutic efficacy with particular reference to depression
16. Quantitative GLC determination of cis- and trans-isomers of doxepin and desmethyldoxepin
17. Estimating the dimension of a model
18. The identification of urinary metabolites of doxepin in patients
19. Identification of phenolic doxepin glucuronides from patient urine and rat bile
20. Single dose pharmacokinetics of doxepin in healthy volunteers
21. Doxepin plasma levels and therapeutic response in depression: Preliminary findings
22. Pharmacokinetic evaluation of two doxepin products
23. High-performance liquid chromatographic determination of (Z)- and (E)-doxepin hydrochloride isomers
24. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations
25. Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography
26. Doxepin kinetics