Melatonin induces changes to serum cytokines in mice infected with the Venezuelan equine encephalomyelitis virus

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 96, Issue 3, 2002, Pages 348-351

  Valero, Nereida ^a   Bonilla, Ernesto ^a,b   Pons, Héctor ^a   Chacin Bonilla, Leonor ^a   Anñez, Florencio ^a   Espina, Luz Marina ^a   Medina Leendertz, Shirley ^b   Tamayo, Jorge Garciía ^c  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

^b Fundacite Zulia   (Venezuela)

^c UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Animal models; Experimental infections; IFN ; IL 1 ; IL 2; IL 4; Melatonin cytokines; Mice; TNF ; Venezuelan equine encephalomyelitis virus

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; MELATONIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENCEPHALOMYELITIS; IMMUNE RESPONSE; MALE; MORTALITY; MOUSE; NONHUMAN; PROTECTION; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; INTERFERON TYPE II; INTERLEUKINS; MALE; MELATONIN; MICE; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

ALPHAVIRUS; ANIMALIA; EQUIDAE; RNA VIRUSES; VENEZUELAN EQUINE ENCEPHALITIS VIRUS;

EID: 0036068495     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(02)90121-5     Document Type: Article

References (34)

1. Immunomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells
2. Protection by melatonin in mice infected with Semliki Forest virus
3. Protective effects of melatonin in mice infected with encephalitis viruses
4. Plaque formation by arboviruses
5. Molecular basis for bi-directional communications between the immune and neuroendocrine system
6. Pyrogenic action of cytokines
7. Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus
8. Mechanism of neuroinvasion of Venezuelan equine encephalitis virus in the mouse
9. Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-alpha in the central nervous system
10. Melatonin induced increase in gamma interferon production by murine splenocytes
11. Hormones and the immunological capacity
12. Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of the immunomodulatory pathway
13. Importancia de la respuesta celular en el fenómeno encefalítico inducido por el virus de la Encefalitis equina Venezolana
14. Melatonin enhances IL-2, IL-6 and IFN-gamma production by human circulating CD4+ cells: A possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes
15. The physiology of melatonin in mammals
16. Role of interferon in resistance to viral infection in vivo
17. Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus
18. Arboviruses
19. A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients
20. T-helper 2 lymphocytes as peripheral target of melatonin signaling
21. Is hematopoiesis under the influence of neural and neuroendocrine mechanism
22. Melatonin and the immune-hematopoietic system therapeutic and adverse pharmacological correlates
23. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibodies response and antagonizes the immunosuppressive effect of corticosterone
24. Role of the pineal gland in immunity. II: Melatonin enhances the antibodies response via an opiatiergic mechanism
25. Hematopoietic rescue via T-cell-dependent, endogenous granulocyte-macrophage colony stimulating factor induced by the pineal neurohormone melatonin in tumor bearing mice
26. Inhibition of IL-1 binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibodies
27. Activation of human monocytes by the pineal hormone melatonin
28. Mechanism of interleukin-12 mediated toxicity during experimental viral infection: Role of tumor necrosis factor and glucocorticosteroids
29. The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon
30. Separation, isolation and immunological studies of the structural proteins of Venezuelan equine encephalomyelitis virus
31. Evidence for a direct action of melatonin on the immune system
32. Cytokine regulation of T-cell function: Potential for therapeutic intervention
33. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system specific expression of tumor necrosis factor α
34. Psychoneuroimmunology: Interactions between central nervous system and immune system