Main physiopathologic mechanisms involved in hepatic drug reactions;Principali meccanismi fisiopatologici coinvolti nel danno epatico da farmaci

Minerva Gastroenterologica e Dietologica

Volumn 48, Issue 2, 2002, Pages 81-88

  Valentini, Giovanni ^a   Capristo, E ^a   Scarfone, A ^a   Mingrone, G ^a   Greco, A V ^a   Gasbarrini, G ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Chemically induced Hepatitis; Cholestasis; Etiology; Liver diseases; Metabolism; Pharmaceutical preparations; Toxic

Indexed keywords

AMIODARONE; ANDROGEN; ARSENIC; AZATHIOPRINE; BUSULFAN; CARBAMAZEPINE; CYTOCHROME P450; DACTINOMYCIN; DEXTROPROPOXYPHENE; ESTROGEN; METHOTREXATE; MITOMYCIN; PARACETAMOL; RETINOL; TAMOXIFEN; THORIUM DIOXIDE; TIOGUANINE; VINYL CHLORIDE;

CHOLESTASIS; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; DOSE LIVER FUNCTION RELATION; DRUG METABOLISM; ENVIRONMENTAL EXPOSURE; HUMAN; LIVER METABOLISM; LIVER TOXICITY; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; TOXIC HEPATITIS;

EID: 0036065940     PISSN: 00264776     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Drug-induced hepatic injury: An analysis of 1100 case reports to The Danish Committee on Adverse Drug Reactions between 1978 and 1987
2. Fegato e farmaci
3. Genetics predisposition to drug-induced hepatotoxicity
4. Effect of age and gender on the activity of human hepaic CYP3A
5. Role of the liver in drug metabolism
6. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
7. A form of cytochrome P-450 in man, orthologous in rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking
8. Oxidatives stress: From basic research to clinical application
9. The immunological mediation of drug reactions affecting the liver
10. Immunotoxicity of the liver: Adverse reactions to drugs
11. Drug-induced liver disease
12. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993)
13. Hepatic failure and lactic acidosis due to fialouridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
14. Hepatic injry associated with the use of nitrofurans: A clinicopathologiacal study of 52 reported cases
15. Liver reaction from trimethoprim
16. Diclofenac associated hepatitis
17. Drug-induced cholestasis
18. Dextropropoxyphene-induced hepatotoxicity: Another cause of the vanishing bile duct syndrome
19. Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice
20. Methotrexate-induced chronic liver injury:guidlines for detection and prevention
21. Drug-induced vascular lesions of the liver
22. Arsenic and non-cirrhotic portal hypertension: A report of eight cases
23. Drug-induced vascular lesion of the liver