Prevention of latently expressed CYP2C11, CYP3A2, and growth hormone defects in neonatally monosodium glutamate-treated male rats by the N-methyl-D-aspartate receptor antagonist dizocilpine maleate

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 490-496

  Kaufhold, Antje ^a   Nigam, Prabhat K ^a   Dhir, Ravindra N ^a   Shapiro, Bernard H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C11; CYTOCHROME P450 3A2; DIZOCILPINE; DIZOCILPINE MALEATE; GLUTAMATE SODIUM; GROWTH HORMONE; HEXOBARBITAL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; ENZYME DEFECT; GENE EXPRESSION; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; GROWTH RETARDATION; HYPOTHALAMUS LESION; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NEWBORN; NONHUMAN; OBESITY; PRIORITY JOURNAL; SLEEP TIME;

ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DIZOCILPINE MALEATE; GROWTH; GROWTH HORMONE; LIVER; MALE; MEMBRANE PROTEINS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM GLUTAMATE; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0036065623     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034785     Document Type: Article

References (35)

1. Sex- and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth hormone regulating hexobarbital metabolism and action
2. Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms
3. Differential expression of gender-dependent hepatic isoforms of cytochrome P-450 by pulse signals in the circulating masculine episodic growth hormone profile of the rat
4. Intrinsic signals in the sexually dimorphic circulating growth hormone profiles of the rat
5. Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence
6. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: Involvement of growth hormone-releasing factor and effects on cytochrome P450 expression
8. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats
9. Programming and differentiation of rat liver enzymes
10. Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats
11. MK-801 selectively protects mouse arcuate neurons in vivo against glutamate toxicity
12. Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor
13. Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16α-hydroxylase cytochrome P-450 apoprotein in the rat
14. Renaturalizing the sexually dimorphic profile of circulating growth hormone in hypophysectomized rats
15. Infusion of gender-dependent plasma growth hormone profiles into intact rats: Effects of subcutaneous, intraperitoneal and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms
16. Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450
17. Dilution of the chemiluminescence reagents reduces the background noise on Western blots
18. Feminization of hepatic cytochrome P-450 by nominal levels of growth hormone in the feminine plasma profile
19. Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile
20. Nominal growth hormone pulses in otherwise normal masculine plasma profiles induce intron retention of expressed hepatic CYP2C11 with associated nuclear splicing deficiency
21. Hepatic P450 expression in hypothyroid rats: Differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11) and RLM2 (IIA2) to thyroid hormone
22. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice
23. Purification and characterization of hepatic microsomal cytochrome P-450
24. Delayed teratogenic expression
25. Gender differences in drug metabolism regulated by growth hormone
26. Normal levels of hepatic drug-metabolizing enzymes in neonatally induced, growth hormone-deficient adult male and female rats
27. Signaling elements in the ultradian rhythm of growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450
28. Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate
29. Androgenic repression of hexobarbitone metabolism and action on Cr1:CD-1 (ICR) BR mice
30. Delay of puberty and impairment of growth in female rats given a noncompetitive antagonist of NMDA receptors
31. Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical and molecular probes
32. Growth hormone action: Signaling via JAK/STAT-coupled receptor
33. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic P-450
34. Growth hormone regulation of male-specific rat liver P-450s 2A2 and 3A2: Induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate
35. 3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes