CD44: Functional relevance to inflammation and malignancy

Histology and Histopathology

Volumn 17, Issue 3, 2002, Pages 945-950

  Yasuda, M ^a   Nakano, K ^a   Yasumoto, K ^a   Tanaka, Yoshiya ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Adhesion Molecules; Cancer; CD44; Inflammation; Recirculation Recruitment

Indexed keywords

BETA1 INTEGRIN; CD44V ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; FAS ANTIGEN; FAS LIGAND; HERMES ANTIGEN; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1;

APOPTOSIS; CANCER; CANCER CELL; CANCER GROWTH; CANCER SUSCEPTIBILITY; CELL ADHESION; CELL AGGREGATION; CELL FUNCTION; CELL INTERACTION; CELL MEDIATED CYTOTOXICITY; COLON CANCER; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC VALUE; EXTRACELLULAR MATRIX; EXTRAVASATION; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE ADHERENCE; LUNG CANCER; LYMPHOCYTE RECIRCULATION; METASTASIS; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVITIS; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD44; COLONIC NEOPLASMS; HUMANS; HYALURONIC ACID; INFLAMMATION; MODELS, BIOLOGICAL; NEOPLASMS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 0036064665     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. CD44 is the principal cell surface receptor for hyaluronate
2. Hyaluronan in joints disease
3. Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1
4. Crosslinking of CD44 on rheumatoid synovial cells augment IL-6 production
5. CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells
6. CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins
7. Effects of hyaluronan on the invasive properties of human breast cancer cells in vitro
8. The importance of cellular environment to function of the CD44 matrix receptor
9. Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes
10. Hyaluronan: A multifunctional, megaDalton, stealth molecule
11. CD44 and its interaction with extracellular matrix
12. Hyaluronan binding by cell surface CD44
13. p53 in rheumtoid arthritis: Friend or foe?
14. CD44: Structure, function, and association with the malignant process
15. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
16. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
17. A crucial role for CD44 in inflammation
18. Systemic characteristics of chronic arthritis induced by transfer of human rheumatoid synovial membrane into SCID mice (human/murine SCID arthritis)
19. Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis
20. CD44 regulates hematopoietic prognitor distribution, granuloma formation, and tumorigenicity
21. The normal structure and function of CD44 and its role in neoplasia
22. Cytokines and adhesion molecules in the pathogenesis of vaculitis
23. Integrin activation by chemokines: Relevance to inflammatory adhesion cascade during T cell migration
24. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β
25. Heparan sulfate proteoglycan on leukemic cells is primarily involved in integrin triggering and its mediated adhesion to endothelial cells
26. Distinct phenotype of leukemic T cells with various tissue tropisms
27. Heparan sulfate proteoglycan on endothelium efficiently induces integrin-mediated T cell adhesion by immobilizing chemokines in rheumatoid synovitis
28. Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells
29. H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells
30. ICAM-1 distinguishes functional heterogeneity of synovial cells in patients with rheumatoid arthritis
31. The hyaluronate receptor is identical to a glycoprotein of 85, 000 Mr (gp 85) as shown by monoclonal antibody that interferes with bindingn activity
32. CD44 glycoproteins in colorectal cancer: Expression, function, and prognostic value
33. CD44 stimulation down-regulates Fax expression and Fas-mediated apoptosis of lung cancer cells
34. Stimulation of beta1 integrin down-regulates ICAM-1 expression and ICAM-1-dependent adhesion of lung cancer cells through focal adhesion kinase