Foetal haemoglobin in normal healthy adults: Relationship with polymorphic sequences cis to the β globin gene

European Journal of Human Genetics

Volumn 10, Issue 5, 2002, Pages 320-326

  Zertal Zidani, Samia ^a,c   Ducrocq, Rolande ^a   Sahbatou, Mourad ^b   Satta, Dalila ^c   Krishnamoorthy, Rajagopal ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b FONDATION JEAN DAUSSET CEPH   (France)

^c Universite Mentouri Constantine   (Algeria)

Author keywords

HPFH; Polymorphisms; globin gene cluster

Indexed keywords

ADENINE; BETA GLOBIN; CYTOSINE; GUANINE; HEMOGLOBIN F; THYMINE;

ADULT; ALGERIA; ARTICLE; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; MALE; NORMAL HUMAN; POPULATION GENETICS; PRIORITY JOURNAL; RANDOMIZATION; SEQUENCE ANALYSIS;

ADOLESCENT; ADULT; FEMALE; FETAL HEMOGLOBIN; GENETIC MARKERS; GLOBINS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 0036063360     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200809     Document Type: Article

References (34)

1. Fetal hemoglobin restriction to a few erythrocytes (F cells) in normal human adults
2. F cells in the adult: Normal values and levels in individuals with hereditary and acquired elevation of HbF
3. Genetic control of F cells in human adults
4. X-linked dominant control of F-cells in normal adult life: Characterization of the Swiss type as hereditary persistence of foetal hemoglobin regulated dominantly by gene(s) on X chromosome
5. Hereditary persistence of fetal hemoglobin and δβ thalassemia
6. Normale und anormale mensliche Haemoglobine
7. Foetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2
8. Dissecting the loci controlling foetal haemoglobin production on chromosomes 11p and 6q by the regressive approach
9. Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome 6q23
10. One haplotype is associated with the Swiss type of hereditary persistence of fetal hemoglobin in the Yugoslavian population
11. Variability in the fetal hemoglobin level of the normal adult
12. The repeated sequence (AT)x (T)y upstream to the beta-globin gene is a simple polymorphism
13. Fetal hemoglobin in sickle cell anemia: Relation to regulatory sequences cis to the beta-globin gene
14. Inter-ethnic polymorphism of the beta-globin gene locus control region (LCR) in sickle-cell anemia patients
15. Variation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals
16. Sequence variations in the 5′ hypersensitive site-2 of the locus control region of beta S chromosomes are associated with different levels of fetal globin in hemoglobin S homozygotes
17. Genetic variations in human fetal globin gene microsatellites and their functional relevance
18. Genetic epidemiology of beta-thalassemia in Sicily: Do sequences 5′ to the G gamma gene and 5′ to the beta gene interact to enhance HbF expression in beta-thalassemia?
19. Combined effect of two different polymorphic sequences within the beta globin gene cluster on the level of HbF
20. DNA sequence variation associated with elevated fetal G gamma globin production
21. Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients
22. High-performance liquid chromatographic separation of human haemoglobins. Simultaneous quantitation of foetal and glycated haemoglobins
23. Rapid identification by denaturing gradient gel electrophoresis of mutations in the gamma-globin gene promoters in non-deletion type HPFH
24. A comprehensive scanning method for rapid detection of beta-globin gene mutations and polymorphisms
25. Detection of common deletional alphathalassemia determinants by PCR
26. Origin and spread of betaglobin gene mutations in India, Africa, and Mediterranea: Analysis of the 5′ flanking and intragenic sequences of beta S and beta C genes
27. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
28. Sequence variations in the 5′ flanking and IVS-II regions of the G gamma- and A gamma-globin genes of beta S chromosomes with five different haplotypes
29. Variation of HbF and F-cell number with the G-gamma XmnI (C→T) polymorphism in normal individuals
30. Genetic influences on F cells and other hematologic variables: A twin heritability study
31. A common protein binds to two silencers 5′ to the human beta-globin gene
32. The silent carrier allele: Beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions
33. Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype