Changes in myosin heavy chain and its localization in rat heart in association with hypobaric hypoxia-induced pulmonary hypertension

Journal of Pathology

Volumn 197, Issue 3, 2002, Pages 380-387

  Nakanishi, Kuniaki ^a   Nakata, Yasuko ^a   Kanazawa, Fumiko ^b   Imamura, Shin Ichiro ^b   Matsuoka, Rumiko ^c   Osada, Hiroshi ^c   Kawai, Toshiaki ^a   Uenoyama, Maki ^a   Aurues, Takashi ^a   Ikeda, Tomosumi ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b Aeromedical Laboratory   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Heart myosin heavy chain; Hypoxia; Lung; Pulmonary hypertension; Rat

Indexed keywords

ISOPROTEIN; MESSENGER RNA; MYOSIN HEAVY CHAIN;

ALTITUDE; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CONTROLLED STUDY; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART RIGHT VENTRICLE; HEART VENTRICLE; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HEART VENTRICLE SEPTUM; HEART VENTRICLE VOLUME; HEART VENTRICLE WALL; HEART WEIGHT; HYPOBARISM; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; HYPERTENSION, PULMONARY; IN SITU HYBRIDIZATION; MALE; MYOCARDIUM; MYOSIN HEAVY CHAINS; PRESSURE; PROTEIN ISOFORMS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036063164     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1132     Document Type: Article

References (31)

1. Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement
2. Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping
3. Molecular characterization of two myosin heavy chain genes expressed in the adult heart
4. Expression of the cardiac ventricular α- and β-myosin heavy chain genes is developmentally and hormonally regulated
5. Myosin isoenzyme redistribution in chronic heart overload
6. Adaptational changes of MHC gene expression and isozyme transition in cardiac overloading
7. Local response to cardiac overload on myosin heavy chain gene expression and isozyme transition
8. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy: Interaction between hemodynamic and thyroid hormone-induced signals
9. Man at High Altitude: The Pathophysiology of Acclimatization and Adaptation
10. The effect of continued hypoxia on rat pulmonary arterial circulation: An ultrastructural study
11. Structure and function in pulmonary hypertension: New perceptions
12. Pulmonary vascular responses in rats exposed to chronic hypobaric hypoxia at two different altitude levels
13. Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension
14. Adaptation of cardiac myosin and creatine kinase to chronic hypoxia: Role of anorexia and hypertension
15. Effects of hypobaric hypoxia on antioxidant enzymes in rats
16. Hypercoagulable state in a hypobaric, hypoxic environment causes nonbacterial thrombotic endocarditis in rats
17. Tissue factor is associated with the nonbacterial thrombotic endocarditis induced by a hypobaric hypoxic environment in rats
18. Thrombopoietin expression in normal and hypobaric hypoxia-induced thrombocytopenic rats
19. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
20. Expression of sense and naturally occurring antisense mRNA of myosin heavy chain in rat heart tissue and cultivated cardiomyocytes
21. Cardiac α- and β-myosin heavy chain genes are organized in tandem
22. Expression of C-type natriuretic peptide during development of rat lung
23. Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats
24. Distribution of α- and β-myosin heavy chains in the ventricular fibers of the postnatal developing rat
25. Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium: An immunohistochemical study
26. Immunolocalization of rat cardiac β-MHC protein expression in systemic hypertension and caloric restriction
27. Nonsynchronous accumulation of α-skeletal actin and β-myosin heavy chain mRNAs during early stages of pressure-overload-induced cardiac hypertrophy demonstrated by in situ hybridization
28. Differences in myosin isoform expression in the subepicardial and subendocardial myocardium during cardiac hypertrophy in the rat
29. Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium
30. Transmural distribution of isomyosin in rabbit ventricle during maturation examined by immunofluorescence and staining for calcium-activated adenosine triphosphatase
31. Systolic and diastolic pressure gradients within the left ventricular wall