Hypothermic injury/cold-induced apoptosis: Not preservation solutions but iron chelators provide protection;Kälteschädigung/kälteinduzierte apoptose: Kein schutz durch konservierungslösungen, aber protektion durch eisenchelatoren

Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

Volumn 14, Issue 2, 2002, Pages 102-109

  Rauen, Ursula ^a   Schulze Frenking, G E ^a   De Groot, H ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Hydroxyl radical; Hypothermia; Iron; Preservation solutions; Reactive oxygen species

Indexed keywords

DEFEROXAMINE; HTK SOLUTION; HYDROXYL RADICAL; IRON; PRESERVATIVE; REACTIVE OXYGEN METABOLITE; UNIVERSITY OF WISCONSIN SOLUTION;

APOPTOSIS; ARTICLE; CELL DAMAGE; COLD INJURY; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHERMIA; IRON CHELATION; LIVER CELL; MEMBRANE PERMEABILITY; ORGAN PRESERVATION; WARMING;

EID: 0036053483     PISSN: 09469648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Principles of solid-organ preservation by cold storage
2. Liver preservation: The past and the future
3. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies
4. Preservation injury: Mechanisms, prevention and consequences
5. Effects of hypothermia upon endothelial cells: Mechanisms and clinical importance
6. Defense strategies against hypoxia and hypothermia
7. Organ preservation
8. Rapid decrease in cellular sodium and chloride content during cold incubation of cultured liver endothelial cells and hepatocytes
9. A role for sodium in hypoxic but not in hypothermic injury to hepatocytes and LLC-PK, cells
10. Involvement of reactive oxygen species in the preservation injury to cultured liver endothelial cells
11. Oxygen-free radical-mediated injury to cultured rat hepatocytes during cold incubation in preservation solutions
12. Injury to cultured liver endothelial cells after cold preservation: Mediation by reactive oxygen species that are released independently of the known trigger hypoxia/reoxygenation
13. Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells
14. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: Mediation by reactive oxygen species
15. 2 formation
16. Cold-induced apoptosis of rat liver cells in University of Wisconsin solution: The central role of chelatable iron
17. The liver and iron
18. Role of free radicals and catalytic metal ions in human disease: An overview
19. The role of iron in oxygen-mediated toxicities
20. The chelatable iron pool in living cells: A methodically defined quantity
21. 2 liberated by sources other than xanthine oxidase
22. Energy-dependent injury to cultured sinusoidal endothelial cells of the rat liver in UW solution
23. Distinct temporal relation among oxygen uptake, malondialdehyde formation, and low-level chemiluminescence during microsomal lipid peroxidation
24. Cold preservation of isolated rabbit proximal tubules induces radical-mediated cell injury
25. Mechanism and prevention of cold storage-induced human renal tubular cell injury
26. Apoptosis versus necrosis during cold storage and rewarming of human renal proximal tubular cells
27. Mammalian cell injury induced by hypothermia - The emerging role for reactive oxygen species
28. The role of DNA damage in the cytotoxic response to hydrogen peroxide/histidine
29. + homeostasis as a critical step in the development of irreversible hepatocyte injury after adenosine triphosphate depletion
30. Sodium-mediated swelling is associated with irreversible damage of isolated hepatocytes exposed to hypoxia or mitochondrial toxins
31. + overload in the rat
32. Protection by glycine against hypoxic injury of rat hepatocytes: Inhibition of ion fluxes through nonspecific leaks
33. + accumulation and hepatocyte injury during cold storage
34. Detection and quantitation of hydroxyl radical using dimethyl sulfoxide as molecular probe