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Volumn , Issue 62, 2002, Pages 309-319

Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; TAU PROTEIN;

EID: 0036052571     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6139-5_29     Document Type: Conference Paper
Times cited : (17)

References (46)
  • 1
    • 0023200370 scopus 로고
    • Histopathological criteria for progressive dementia disorders: Clinical-pathological correlation and classification by multivariate data analysis
    • Berlin
    • Alafuzoff I, Iqbal K, Friden H, Adolfson R, Winblad B (1987) Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol (Berlin) 74: 209-225
    • (1987) Acta Neuropathol , vol.74 , pp. 209-225
    • Alafuzoff, I.1    Iqbal, K.2    Friden, H.3    Adolfson, R.4    Winblad, B.5
  • 2
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso A del C, Zaidi T, Grundke-Iqbal I, Iqbal K (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 91: 5562-5566
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.D.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 3
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso A del C, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2: 783-787
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso, A.D.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 4
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau
    • Alonso A del C, Grundke-Iqbal I, Barra HS, Iqbal K (1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 94: 298-303
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 298-303
    • Alonso, A.D.C.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 5
    • 0035811050 scopus 로고    scopus 로고
    • Hyperphosphorylation induces self - Assembly of tau into tangles of paired helical filaments/straight filaments
    • Alonso A del C, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (2001a) Hyperphosphorylation induces self - assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci USA 98: 6923-6928
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6923-6928
    • Alonso, A.D.C.1    Zaidi, T.2    Novak, M.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 6
    • 0035851157 scopus 로고    scopus 로고
    • Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein
    • Alonso A del C, Zaidi T, Novak HS, Barra HS, Grundke-Iqbal I, Iqbal K (2001b) Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. J Biol Chem 276: 37967-37973
    • (2001) J Biol Chem , vol.276 , pp. 37967-37973
    • Alonso, A.D.C.1    Zaidi, T.2    Novak, H.S.3    Barra, H.S.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 7
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arrigada PA, Growdon JH, Hedley-White ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arrigada, P.A.1    Growdon, J.H.2    Hedley-White, E.T.3    Hyman, B.T.4
  • 9
    • 0035830740 scopus 로고    scopus 로고
    • Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356
    • Bennecib M, Gong C-X, Grundke-Iqbal I, Iqbal K (2001) Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS Lett 490: 15-22
    • (2001) FEBS Lett , vol.490 , pp. 15-22
    • Bennecib, M.1    Gong, C.-X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 10
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen P (1989) The structure and regulation of protein phosphatases. Ann Rev Biochem 58: 453-508
    • (1989) Ann Rev Biochem , vol.58 , pp. 453-508
    • Cohen, P.1
  • 12
    • 0023809230 scopus 로고
    • Alzheimer's disease: A double-labeling immunohistochemical study of senile plaques
    • Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH (1988) Alzheimer's disease: a double-labeling immunohistochemical study of senile plaques. Am J Pathol 132: 86-101
    • (1988) Am J Pathol , vol.132 , pp. 86-101
    • Dickson, D.W.1    Farlo, J.2    Davies, P.3    Crystal, H.4    Fuld, P.5    Yen, S.H.6
  • 14
    • 0030713963 scopus 로고    scopus 로고
    • Genetics of aging
    • Finch C, Tanzi RE (1997) Genetics of aging. Science 278: 407-411
    • (1997) Science , vol.278 , pp. 407-411
    • Finch, C.1    Tanzi, R.E.2
  • 15
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3: 519-526
    • (1989) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 16
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer disease brain
    • Gong C-X, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61: 921-927
    • (1993) J Neurochem , vol.61 , pp. 921-927
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 17
    • 0029113874 scopus 로고
    • Phosphatase activity towards abnormally phosphorylated τ: Decrease in Alzheimer disease brain
    • Gong C-X, Shaikh S, Wang J-Z, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Phosphatase activity towards abnormally phosphorylated τ: decrease in Alzheimer disease brain. J Neurochem 65: 732-738
    • (1995) J Neurochem , vol.65 , pp. 732-738
    • Gong, C.-X.1    Shaikh, S.2    Wang, J.-Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 18
    • 0034088846 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain
    • Gong C-X, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K (2000) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. J Biol Chem 275: 5535-5544
    • (2000) J Biol Chem , vol.275 , pp. 5535-5544
    • Gong, C.-X.1    Lidsky, T.2    Wegiel, J.3    Zuck, L.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 21
    • 0036107977 scopus 로고    scopus 로고
    • Levels of nonphosphorylated and phosphorylated tau in CSF of Alzheimer disease patients: An ultrasensitive bienzyme-substrate-recycle ELISa
    • Hu YY, He SS, Wang X, Duan QH, Grundke-Iqbal I, Iqbal K, Wang JZ (2002) Levels of nonphosphorylated and phosphorylated tau in CSF of Alzheimer disease patients: an ultrasensitive bienzyme-substrate-recycle ELISa. Am J Pathol 160: 1269-1278
    • (2002) Am J Pathol , vol.160 , pp. 1269-1278
    • Hu, Y.Y.1    He, S.S.2    Wang, X.3    Duan, Q.H.4    Grundke-Iqbal, I.5    Iqbal, K.6    Wang, J.Z.7
  • 22
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, et al (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393: 702-705
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1
  • 23
    • 0033915577 scopus 로고    scopus 로고
    • Metabolic hypothesis, mechanism and therapeutic targets of Alzheimer neurofibrillary degeneration
    • Iqbal K, Grundke-Iqbal I (2000) Metabolic hypothesis, mechanism and therapeutic targets of Alzheimer neurofibrillary degeneration. Neurosci News 3: 14-20
    • (2000) Neurosci News , vol.3 , pp. 14-20
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 25
  • 26
    • 0028361538 scopus 로고
    • Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation
    • Iqbal K, Zaidi T, Bancher C, Grundke-Iqbal I (1994) Alzheimer paired helical filaments: restoration of the biological activity by dephosphorylation. FEBS Lett 349: 104-108
    • (1994) FEBS Lett , vol.349 , pp. 104-108
    • Iqbal, K.1    Zaidi, T.2    Bancher, C.3    Grundke-Iqbal, I.4
  • 28
    • 0023905906 scopus 로고
    • Clinical, pathological and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
    • Katzman R, Terry RD, DeTeresa R, Brown R, Davies P, Fuld P, Renling X, Peck A (1988) Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23: 138-144
    • (1988) Ann Neurol , vol.23 , pp. 138-144
    • Katzman, R.1    Terry, R.D.2    DeTeresa, R.3    Brown, R.4    Davies, P.5    Fuld, P.6    Renling, X.7    Peck, A.8
  • 29
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1992) Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59: 750-753
    • (1992) J Neurochem , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 30
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 351: 80-84
    • (1994) FEBS Lett , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 31
    • 0027361281 scopus 로고
    • Microtubule associated protein tau: Abnormal phosphorylation of non-paired helical filament pool in Alzheimer disease
    • Köpke E, Tung Y-C, Shaikh S, Alonso A del C, Iqbal K, Grundke-Iqbal I (1993) Microtubule associated protein tau: abnormal phosphorylation of non-paired helical filament pool in Alzheimer disease. J Biol Chem 268: 24374-24384
    • (1993) J Biol Chem , vol.268 , pp. 24374-24384
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Alonso, A.D.C.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 32
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee VM-Y, Balin BJ, Otvos Jr L, Trojanowski JQ (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251: 675-678
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos L., Jr.3    Trojanowski, J.Q.4
  • 33
    • 0028931302 scopus 로고
    • Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney
    • Li M, Guo H, Damuni Z (1995) Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. Biochemistry 34: 1988-1996
    • (1995) Biochemistry , vol.34 , pp. 1988-1996
    • Li, M.1    Guo, H.2    Damuni, Z.3
  • 34
    • 0029665228 scopus 로고    scopus 로고
    • PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A
    • PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry 35: 6998-7002
    • (1996) Biochemistry , vol.35 , pp. 6998-7002
    • Li, M.1    Makkinje, A.2    Damuni, Z.3
  • 35
    • 0029889342 scopus 로고    scopus 로고
    • The Myeloid Leukemia-associated protein SET is a potent inhibitor of Protein Phosphatase 2A
    • Li M, Makkinje A, Damuni Z (1996b) The Myeloid Leukemia-associated protein SET is a potent inhibitor of Protein Phosphatase 2A. J Biol Chem 271: 11059-11062
    • (1996) J Biol Chem , vol.271 , pp. 11059-11062
    • Li, M.1    Makkinje, A.2    Damuni, Z.3
  • 36
    • 0026500429 scopus 로고
    • In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease
    • Mah VH, Eskin TA, Kazee AM, Lapham L, Higgins GA (1992) In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease. Brain Res Mol Brain Res 12: 85-94
    • (1992) Brain Res Mol Brain Res , vol.12 , pp. 85-94
    • Mah, V.H.1    Eskin, T.A.2    Kazee, A.M.3    Lapham, L.4    Higgins, G.A.5
  • 37
    • 0033028074 scopus 로고    scopus 로고
    • Neurons may live for decades with neurofibrillary tangles
    • Morsch R, Simon W, Coleman PD (1999) Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 58: 188-197
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 188-197
    • Morsch, R.1    Simon, W.2    Coleman, P.D.3
  • 38
    • 0032159462 scopus 로고    scopus 로고
    • Physiologic importance of protein phosphatase inhibitors
    • Oliver CJ, Shenolikar S (1998) Physiologic importance of protein phosphatase inhibitors. Frontiers Biosci 3: 961-972
    • (1998) Frontiers Biosci , vol.3 , pp. 961-972
    • Oliver, C.J.1    Shenolikar, S.2
  • 41
    • 0030813618 scopus 로고    scopus 로고
    • Biochemical characterization of mapmodulin, a protein that binds microtubule-associated proteins
    • Ulitzur N, Rancano C, Pfeffer SR (1997) Biochemical characterization of mapmodulin, a protein that binds microtubule-associated proteins. J Biol Chem 272: 30577-30582
    • (1997) J Biol Chem , vol.272 , pp. 30577-30582
    • Ulitzur, N.1    Rancano, C.2    Pfeffer, S.R.3
  • 42
    • 0026693436 scopus 로고
    • Can, a putative oncogene associated with Myeloid Leukemogenesis, may be activated by fusion of its 3′ half to different genes: Characterization of the set gene
    • von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (1992) can, a putative oncogene associated with Myeloid Leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Mol Cell Biol 12: 3346-3355
    • (1992) Mol Cell Biol , vol.12 , pp. 3346-3355
    • Von Lindern, M.1    Van Baal, S.2    Wiegant, J.3    Raap, A.4    Hagemeijer, A.5    Grosveld, G.6
  • 43
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • Wang J-Z, Gong C-X, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 270: 4854-4860
    • (1995) J Biol Chem , vol.270 , pp. 4854-4860
    • Wang, J.-Z.1    Gong, C.-X.2    Zaidi, T.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 44
    • 0029995590 scopus 로고    scopus 로고
    • Restoration of biological activity of Alzheimer abnormally phosphorylated by dephosphorylation with protein phosphatase-2A, -2B and -1
    • Wang J-Z, Grundke-Iqbal I, Iqbal K (1996) Restoration of biological activity of Alzheimer abnormally phosphorylated by dephosphorylation with protein phosphatase-2A, -2B and -1. Mol Brain Res 38: 200-208
    • (1996) Mol Brain Res , vol.38 , pp. 200-208
    • Wang, J.-Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 45
    • 0025994387 scopus 로고
    • Protein phosphorylation and neuronal function
    • Walaas SI, Greengard P (1991) Protein phosphorylation and neuronal function. Pharmacol Rev 43: 299-349
    • (1991) Pharmacol Rev , vol.43 , pp. 299-349
    • Walaas, S.I.1    Greengard, P.2


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