Melan A and S100 Protein Immunohistochemistry in Feline Melanomas: 48 Cases

Veterinary Pathology

Volumn 39, Issue 1, 2002, Pages 127-132

  Ramos Vara, J A ^a   Miller, M A ^a   Johnson, G C ^a   Turnquist, S E ^a   Kreeger, J M ^a   Watson, G L ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cats; immunohistochemistry; Melan A; melanoma; S100 protein

Indexed keywords

MART1 ANTIGEN; PROTEIN S 100; TUMOR ANTIGEN; TUMOR PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CAT DISEASE; CLASSIFICATION; IMMUNOHISTOCHEMISTRY; MELANOMA; PATHOLOGY; SKIN; SKIN TUMOR;

ANIMALS; ANTIGENS, NEOPLASM; CAT DISEASES; CATS; IMMUNOHISTOCHEMISTRY; MELANOMA; NEOPLASM PROTEINS; S100 PROTEINS; SKIN; SKIN NEOPLASMS;

EID: 0036050938     PISSN: 03009858     EISSN: 15444221     Source Type: Journal    
DOI: 10.1354/vp.39-1-127     Document Type: Article

References (21)

1. Akutsu Y, Jimbow K: Development and characterization of a mouse monoclonal antibody, MoAb HMSA-1, against a melanosomal fraction of human malignant melanoma. Cancer Res 46: 2904–2911, 1986
2. Berrington AJ, Jimbow K, Haines DM: Immunohistochemical detection of melanoma-associated antigens on formalin-fixed, paraffin-embedded canine tumors. Vet Pathol 31: 455–461, 1994
3. Busam KJ, Chen Y-T, Old LJ, Stockert E, Iversen K, Coplan KA, Rosai J, Barnhill RL, Jungbluth AA: Expression of Melan-A (MART1) in benign melanocytic nevi and primary cutaneous malignant melanoma. Am J Surg Pathol 22: 976–982, 1998
4. Busam KJ, Jungbluth AA: Melan-A, a new melanocytic differentiation marker. Adv Anat Pathol 6: 12–18, 1999
5. Day MJ, Lucke VM: Melanocytic neoplasia in the cat. J Small Anim Pract 36: 207–213, 1995
6. Goldschmidt MH, Liu SMS, Shofer FS: Feline dermal melanoma: a retrospective study. Adv Vet Dermatol 2: 285–291, 1993
7. Goldschmidt MH, Shofer FS: Sebaceous tumors. In: Skin Tumors of the Dog and Cat, ed. Goldschmidt MH, Shofer FS, pp. 50–65. Pergamon Press, Oxford, UK, 1992
8. Goldschmidt MH, Shofer FS: Melanoma. In: Skin Tumors of the Dog and Cat, ed. Goldschmidt MH, Shofer FS, pp. 131–141. Pergamon Press, Oxford, UK, 1992
9. Jungbluth AA, Busam KJ, Gerald WL, Stockert E, Coplan KA, Iversen K, MacGregor DP, Old LJ, Chen Y-T: An anti-Melan-A monoclonal antibody for the detection of malignant melanoma in paraffin-embedded tissues. Am J Surg Pathol 22: 595–602, 1998
10. Kamino H, Tam ST: Immunoperoxidase technique modified by counterstain with Azure B as a diagnostic aid in evaluating heavily pigmented melanocytic neoplasms. J Cutan Pathol 18: 436–439, 1991
11. Miller MA, Nelson SL, Turk JR, Pace LW, Brown TP, Shaw DP, Fischer JR, Gosser HS: Cutaneous neoplasia in 340 cats. Vet Pathol 28: 389–395, 1991
12. Miller WH, Scott DW, Anderson WI: Feline cutaneous melanocytic neoplasms: a retrospective analysis of 43 cases (1979–1991). Vet Dermatol 4: 19–26, 1993
13. Patnaik AK, Mooney S: Feline melanoma: a comparative study of ocular, oral, and dermal neoplasms. Vet Pathol 25: 105–112, 1988
14. Ramos-Vara JA, Beissenherz MB: Antigen retrieval methods to optimize diagnostic immunohistochemistry: experience with 63 markers. J Vet Diagn Invest 12: 307–311, 2000
15. Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Kreeger JM, Pace LW, Turk JR, Turnquist SE, Watson GL, Yamini B: Immunoreactivity of A103, an antibody to Melan A, in canine steroid-producing tissues and their tumors. J Vet Diagn Invest 13: 328–332, 2001
16. Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Pace LW, Fard A, Kottler SJ: Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Vet Pathol 37: 597–608, 2000
17. Ruiter DJ, Bröcker E-B: Immunohistochemistry in the evaluation of melanocytic tumors. Semin Diagn Pathol 10: 76–91, 1993
18. Schaumburg-Lever G, Metzler G, Kaiserling E: Ultrastructural localization of HMB-45 binding sites. J Cutan Pathol 18: 432–435, 1991
19. Takahashi K, Isobe T, Ohtsuki Y, Akagi T, Sonobe H, Okuyama T: Immunohistochemical study on the distribution of α and β subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch B Cell Pathol 45: 385–396, 1984
20. Van der Linde-Sipman JS, de Wit MML, van Garderen E, Molenbeek RF, van der Velde-Zimmermann D, de Weger RA: Cutaneous malignant melanomas in 57 cats: identification of (amelanotic) signet-ring and balloon cell types and verification of their origin by immunohistochemictry, electron microscopy, and in situ hybridization. Vet Pathol 34: 31–38, 1997
21. Vennegoor C, Hageman Ph, Van Nouhuijs H, Ruiter DJ, Calafat J, Ringens PJ, Rümke Ph: A monoclonal antibody specific for cells of the melanocyte lineage. Am J Pathol 130: 179–192, 1988