Intratumoral injection of dendritic and irradiated glioma cells induces anti-tumor effects in a mouse brain tumor model

Cancer Immunology, Immunotherapy

Volumn 51, Issue 8, 2002, Pages 424-430

  Kikuchi, Tetsuro ^a   Akasaki, Yasuharu ^a   Abe, Toshiaki ^a   Ohno, Tsuneya ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Astrocytoma; Dendritic cell; Glioma; Immunotherapy; Irradiation

Indexed keywords

CD8 ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CELL ACTIVITY; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DISEASE MODEL; FEMALE; GLIOMA CELL; IMMUNIZATION; IRRADIATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; T LYMPHOCYTE; TREATMENT OUTCOME; TUMOR IMMUNITY;

ANIMALS; ASTROCYTOMA; BRAIN NEOPLASMS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DENDRITES; GLIOMA; IMMUNOTHERAPY; KILLER CELLS, NATURAL; LYMPH NODES; MICE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0036046174     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-002-0297-z     Document Type: Article

References (34)

1. Antitumor effect of immunizations with fusions of dendritic and glioma cells in a mouse brain tumor model
2. Expression of murine interleukin-7 in a murine glioma cell line results in reduced tumorigenicity in vivo
3. Role of tumor cell apoptosis in tumor antigen migration to the draining lymph nodes
4. Medical treatment of high-grade malignant gliomas in adults: An overview
5. Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection
6. Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats
7. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
8. Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia
9. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
10. Decreased antigen presentation by dendritic cells in patients with breast cancer
11. Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long-lasting antitumor immunity
12. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes
13. + T cell-dependent tumor rejection
14. Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells
15. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
16. Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin-12 against mouse glioma cells located in the central nervous system
17. Tumor regression induced by intratumor administration of adenovirus vector expressing CD40 ligand and naive dendritic cells
18. Dendritic cells prolong tumor-specific T-cell survival and effector function after interaction with tumor targets
19. Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts
20. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
21. Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin-12
22. Bone marrow-derived dendritic cells pulsed with a tumor-specific peptide elicit effective anti-tumor immunity against intracranial neoplasms
23. Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins
24. Retroviral transduction of human dendritic cells with a tumor-associated antigen gene
25. Potential usefulness of a cultured glioma cell line induced by Rous sarcoma virus in B10.A mouse as an immunotherapy model
26. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
27. Dead or alive: Immunogenicity of human melanoma cells when presented by dendritic cells
28. The dendritic cell system and its role in immunogenicity
29. Autologous human dendriphages pulsed with synthetic or natural tumor peptides elicit tumor-specific CTLs in vitro
30. Minimal recruitment and activation of dendritic cells within renal cell carcinoma
31. Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: Enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha
32. Intensified antitumor immunity by a cancer vaccine that produces granulocyte-macrophage colony-stimulating factor plus interleukin-4
33. Enhancement of human cord blood CD34(+) cell-derived NK cell cytotoxicity by dendritic cells
34. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines