Circulating hematopoietic progenitor cells in a fetus with alpha thalassemia: Comparison with the cells circulating in normal and non-thalassemic anemia fetuses and implications for in utero transplantations

Bone Marrow Transplantation

Volumn 30, Issue 2, 2002, Pages 75-80

  Migliaccio, A R ^a,b   Migliaccio, G ^a,b   Di Baldassarre, A ^b   Eddleman, K ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Fetal therapy; In utero transfusion; In utero transplantation; Progenitor cells; thalassemia

Indexed keywords

CD34 ANTIGEN;

ALPHA THALASSEMIA; ARTICLE; BLOOD; CASE CONTROL STUDY; CASE REPORT; CELL COUNT; COMPARATIVE STUDY; CYTOLOGY; FATHER; FETUS; FETUS BLOOD; FETUS DISEASE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MALE; PRENATAL DEVELOPMENT; TREATMENT OUTCOME; ANEMIA; CELL CULTURE; CELL DIFFERENTIATION; CELL KINETICS; CLINICAL PROTOCOL; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; EVALUATION; FETUS BLOOD SAMPLING; GESTATIONAL AGE; HUMAN CELL; INTRAUTERINE BLOOD TRANSFUSION; LYMPHOCYTE TRANSFUSION; PRIORITY JOURNAL; T LYMPHOCYTE;

ALPHA-THALASSEMIA; ANTIGENS, CD34; CASE-CONTROL STUDIES; CELL COUNT; FATHERS; FETAL BLOOD; FETAL DISEASES; FETUS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; TREATMENT OUTCOME;

EID: 0036046007     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703599     Document Type: Article

References (33)

1. Human embryonic haemoglobins
2. Erythropoiesis
3. Hydropsis fetalis caused by α-thalassemia: An emerging health care problem
4. Intrauterine therapy for homozygous α-thalassemia
5. Limb defects and congenital anomalies of the genitalia in an infant with homozygous alpha-thalassemia
6. Normal development of an infant with α-thalassemia
7. Microchimerism and tolerance following intrauterine transplantation and transfusion for α-Thalassemia-1
8. Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow
9. In utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDX1)
10. In utero transplantation for thalassemia
11. In utero hematopoietic stem cell transplantation: Ontogenic opportunities and biological barriers
12. Circulating hematopoietic stem cell populations in human fetuses: Implications for fetal gene therapy and alterations with in utero red cell transfusion
13. Fetal thrombocytopenia: A retrospective survey of 5194 fetal blood samplings
14. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: Graft progenitor cell content is a better predictor than nucleated cell quantity
15. Identification and characterization of three classes of erythroid progenitors in human fetal liver
16. Globin chain electrophoresis: A new approach to the determination of the Gγ/Aγ ratio in fetal haemoglobin and to studies of globin synthesis
17. Birth-weight-for-gestational-age patterns by race, sex, and parity in the United States population
18. Biosynthesis of Hb in individual fetal liver bursts: Gamma-chain production peaks earlier than beta-chain in the erythropoietic pathway
19. Biosynthesis of globin chains in fetal liver and adult marrow cultures. Comparative analysis of individual colonies derived from early intermediate or late erythroid progenitors
20. Hemoglobin synthesis in individual bursts from normal and adult blood: All bursts and subcolonies synthesize G gamma and A gamma globin chains
21. Rapid diagnosis of α-thalassemia-1 of Southeast Asia type and hydrops fetalis by polymerase chain reaction
22. + cord blood cells in the presence of recombinant human stem cell factor
23. Competitive repopulation in unirradiated normal recipients
24. v mice
25. Functional characterization of early lymphoid precursor cells generated in serum-deprived culture stimulated with stem cell factor and interleukin 7 from normal and autoimmune mice
26. Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice
27. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
28. + hematopoietic stem/progenitor cells in fetal cord blood
29. Fetal cord blood as an alternative source of hematopoietic progenitor cells: Immunophenotype, maternal cell contamination and ex vivo expansion
30. CD34: Structure, biology and clinical utility
31. Reversible expression of CD34 by murine hemopoietic stem cells
32. Fetal bone marrow as a source of stem cells for in utero or postnatal transplantation
33. Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: Influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment