Interference of PR3-ANCA with the enzymatic activity of PR3: Differences in patients during active disease or remission of Wegener's granulomatosis

Clinical and Experimental Immunology

Volumn 129, Issue 3, 2002, Pages 562-570

  Van Der Geld, Y M ^a   Tool, A T J ^b   Videler, J ^b   De Haas, M ^b   Cohen Tervaert, J W ^a   Stegeman, C A ^a   Limburg, P C ^a   Kallenberg, C G M ^a   Roos, D ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

1 antitrypsin; Enzymatic activity of PR3; PR3 ANCA; Wegener's granulomatosis

Indexed keywords

ALPHA 1 ANTITRYPSIN; CASEIN; EPITOPE; IMMUNOGLOBULIN G; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADULT; AGED; ANTIBODY TITER; ANTIGEN RECOGNITION; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; FEMALE; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REMISSION; WEGENER GRANULOMATOSIS;

ADULT; AGED; ALPHA 1-ANTITRYPSIN; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; CASEINS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MYELOBLASTIN; OLIGOPEPTIDES; RECURRENCE; REMISSION, SPONTANEOUS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; WEGENER GRANULOMATOSIS;

EID: 0036040519     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01926.x     Document Type: Article

References (28)

1. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener's granulomatosis
2. Association between active Wegener's granulomatosis and anticytoplasmic antibodies
3. Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils
4. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase
5. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme
6. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties
7. Structure of a serpin-protease complex shows inhibition by deformation
8. ANCA predicting relapse in systemic vasculitis
9. Titration of antibodies against neutrophil cytoplasmic antigens is useful in monitoring disease activity in systemic vasculitides
10. Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre
11. The value of serial ANCA testing during follow-up studies in patients with ANCA-associated vasculitides. A review
12. Limited prognostic value of changes in antineutrophil cytoplasmic antibody titers in patients with Wegener's granulomatosis
13. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis: A predominant role for the IgG3 subclass of ANCA
14. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicalsin vitro
15. Antibodies against granule proteins activate neutrophils in vitro
16. Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity
17. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis
18. Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis
19. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis
20. Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis
21. Delineation of a standard procedure for indirect immunofluorescence detection of ANCA
22. A technical note on the routinely performed ANCA detection
23. Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis
24. Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3
25. Recombinant Proteinase 3 produced in different expression systems: Recognition by anti-PR3 antibodies
26. Reactivities with recombinant human proteinase 3 of c-ANCA autoantibodies in patients with Wegener's granulomatosis
27. Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site
28. Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3