Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle

Journal of Neurology

Volumn 249, Issue 8, 2002, Pages 1004-1009

  Mitsui, Takao ^a   Azuma, Hiroyuki ^a   Nagasawa, Masakazu ^b   Iuchi, Takahiko ^a   Akaike, Masashi ^a   Odomi, Masaaki ^b   Matsumoto, Toshio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Aerobic exercise; Biopsied skeletal muscle; Corticosteroid myopathy; Mitochondrial respiratory activity; Oxidative damage

Indexed keywords

CELL NUCLEUS DNA; CORTICOSTEROID; LACTIC ACID; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; PREDNISOLONE;

ADULT; AGED; ARTICLE; BICYCLE ERGOMETER; BIOSYNTHESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOSTEROID THERAPY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; EXERCISE TEST; FEMALE; HUMAN; HUMAN TISSUE; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE BIOPSY; MYOPATHY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL;

ADRENAL CORTEX HORMONES; CASE-CONTROL STUDIES; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; EXERCISE TEST; FEMALE; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; MITOCHONDRIA; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE STRESS; OXIDOREDUCTASES; PYRUVIC ACID; SUCCINATE DEHYDROGENASE; TIME FACTORS;

EID: 0036039813     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-002-0774-5     Document Type: Article

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