Investigation of deformability, viscosity, and aggregation of mPEG-modified erythrocytes

Biomedical Sciences Instrumentation

Volumn 38, Issue , 2002, Pages 333-338

  Leach, J Kent ^a   Hinman, Alissa ^a   O'Rear, Edgar A ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Erythrocyte deformability; Polyethylene glycol; Stealth erythrocyte; Transfusion; Universal blood type

Indexed keywords

ANTIGENS; BIOLOGICAL MEMBRANES; BLOOD; CELLS; POLYETHYLENE GLYCOLS; PORE SIZE; VISCOSITY;

RED BLOOD CELLS;

BIOMEDICAL ENGINEERING;

BLOOD GROUP ANTIGEN; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; BLOOD DONOR; BLOOD GROUP TYPING; BLOOD TRANSFUSION; CHRONIC DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; COVALENT BOND; CRISIS INTERVENTION; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; FLOW KINETICS; HUMAN; HUMAN CELL; PROTEIN MODIFICATION; SHEAR RATE; SUSPENSION; VISCOSITY;

ANALYSIS OF VARIANCE; BLOOD GROUPING AND CROSSMATCHING; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; HUMANS; POLYETHYLENE GLYCOLS; PRESSURE; STRESS, MECHANICAL; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 0036039013     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
2. Decreased agglutinability of methoxy-polyethylene glycol attached red blood cells: Significance as a blood substitute
3. Chemical camouflage of antigenic determinants: Stealth erythrocytes
4. Structural and functional and consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol)
5. Covalent binding of poly(ethylene glycol) (PEG) to the surface of red blood cells inhibits aggregation and reduces low shear blood viscosity
6. Polyethylene glycol-coated red blood cells fail to bind glycophorin A-specific antibodies and are impervious to invasion by the Plasmodiumfalciparum malaria parasite
7. Covalent binding of polyethylene glycol to the surface of red blood cells as detected and followed up by cell electrophoresis and rheological methods
8. Synthesis, isolation, and characterization of conjugates of ovalbumin with monomethoxypolyethylene glycol using cyanuric chloride as the coupling agent
9. Sickle cell anemia fact sheet
10. Further investigations of red cell deformability with nickel mesh
11. Role of protein adsorption in micropore passability of red blood cells
12. Reduced red cell filtrability due to red cell plasma protein interactions
13. Red blood deformability and protien adsorption on red blood cell surface