Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in erythroid progenitors: Differential pathways for erythropoietin and iron-dependent regulation

British Journal of Haematology

Volumn 118, Issue 2, 2002, Pages 619-626

  Zoller, Heinz ^a   Decristoforo, Clemens ^a   Weiss, Günter ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Erythroid cells; Erythropoietin; Haem biosynthesis; Iron metabolism; Iron regulatory proteins

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; FERROCHELATASE; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROTEIN; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ERYTHROID PRECURSOR CELL; GENE CONSTRUCT; HEME SYNTHESIS; HUMAN; HUMAN CELL; INCUBATION TIME; IRON METABOLISM; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPORTER GENE; RNA TRANSLATION;

5-AMINOLEVULINATE SYNTHETASE; ANIMALS; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; CELLS, CULTURED; ERYTHROID PROGENITOR CELLS; ERYTHROPOIETIN; FERROCHELATASE; GENES, REPORTER; HEME; HUMANS; IRON; IRON-BINDING PROTEINS; MICE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0036037048     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03626.x     Document Type: Article

References (35)

1. Erythropoietin controls heme metabolic enzymes in normal human bone marrow culture
2. Iron transport across biologic membranes
3. The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control
4. Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages
5. Complex regulation of transferrin receptors during erythropoietin-induced differentiation of J2E erythroid cells - Elevated transcription and mRNA stabilisation produce only a modest rise in protein content
6. Differences in the RNA binding sites of iron regulatory proteins and potential target diversity
7. Erythroid 5-aminolevulinate synthase is located on the X chromosome
8. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
9. Measurement of 5-aminolevulinic acid synthase activity in whole and fractionated human bone marrow: Effect of myeloid cell lysis by monoclonal antibody
10. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
11. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
12. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice
13. Mouse erythroleukemia cells
14. Analysis of RNA structure and synthesis
15. Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences
16. Clinical application of Percoll gradient-separated bone marrow
17. Biology of erythropoietin
18. Human peripheral blood and bone marrow cell separation using density gradient centrifugation on Lymphoprep and Percoll in haematological diseases
19. Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element
20. An HPLC assay for rat liver ferrochelatase activity
21. Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis
22. Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells
23. Mechanisms of iron transport into rat erythroid cells
24. The transferrin receptor: Role in health and disease
25. Function and regulation of transferrin and ferritin
26. Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: Role of selective iron regulatory protein-2 downregulation
27. Regulation of erythroid 5-aminolevulinate synthase expression during erythropoiesis
28. Translational control of erythroid delta-aminolevulinate synthase in immature human erythroid cells by heme
29. The G185R mutation disrupts function of the iron transporter Nramp2
30. Functional and molecular responses of human intestinal Caco-2 cells to iron treatment
31. Ferritin expression in maturing normal human erythroid precursors
32. Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1
33. Iron regulates nitric oxide synthase activity by controlling nuclear transcription
34. Regulation of cellular iron metabolism by erythropoietin: Activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells
35. Multiple regulatory steps in erythroid heme biosynthesis