Effects of lead and selenium on telomere binding protein Rap1p, telomerase and telomeric DNA in Saccharomyces cerevisiae

Acta Biochimica et Biophysica Sinica

Volumn 34, Issue 2, 2002, Pages 240-244

  Cui, Qing Hua ^a   Tang, Chia Chun ^a   Huang, You Guo ^b  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Pb and Se; Saccharomyces cerevisiae; Telomerase; Telomere binding protein Rap1p; Telomere length

Indexed keywords

BINDING PROTEIN; DNA; LEAD; PROTEIN RAP1P; SELENIUM; TELOMERASE; UNCLASSIFIED DRUG; FUNGAL DNA; RAP1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TELOMERE BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL DEATH; CELL REGENERATION; CELL VIABILITY; CHROMOSOME SIZE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; NONHUMAN; PROTEIN SECONDARY STRUCTURE; SACCHAROMYCES CEREVISIAE; TELOMERE; AGAR GEL ELECTROPHORESIS; CELL DIVISION; GENETICS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

CELL DIVISION; DNA, FUNGAL; ELECTROPHORESIS, AGAR GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LEAD; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SELENIUM; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 0036032355     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Fahmy MA. Lead acetate genotoxicity in mice. Cytologia, 1999, 64(4): 357-365
2. Xu J, Wise JP, Patierno SR. DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells. Mutat Res, 1992, 280: 129-136
3. Todd AC, Wetmur JG, Moline JM, Godbold JH, Levin SM, Landrigan PJ. Unraveling the chronic toxicity of lead: An essential priority for environmental health. Environ Health Perspect, 1996, 104(suppl): 141-146
4. Hartwig A, Schlepegrell R, Beyersmann D. Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells. Mutat Res, 1990, 241: 75-82
5. Greider CW. Telomeres do D-loop-T-loop. Cell, 1999, 97: 419-422
6. Kyrion G, Boakye KA, Lustig AJ. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol, 1992, 12: 5159-5173
7. Ray A, Runge KW. The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation. Mol Cell Biol, 1998, 18: 1284-1295
8. McEachern MJ, Blackburn EH. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature, 1995, 376: 403-409
9. Cui Q, Tang C. Effects of lead and selenium on yeast (Saccharomyces cerevisia) telomere. J Environ Sci Health, 2000, A35: 1663-1671
10. Le S, Moore JK, Harber JE, Greider CW. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics, 1999, 152: 143-152
11. Nugent CI, Bosco G, Ross O, Evans SK, Salinger AP, Moore JK, Haber JE. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol, 1998, 8: 657-660
12. Runge KW, Zakian VA. Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation. Mol Cell Biol, 1989, 9: 1488-1497
13. Conrad MN, Wright JH, Wolf AJ, Zakian VA. RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability. Cell, 1990, 63: 739-750
14. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM et al. Specific association of human telomerase activity with immortal cells and cancer. Science, 1994, 266: 2011-2015
15. Tang C, Lin J, Chen H. The physiological effects of selenium supplementation on patients with senile diseases. Fresenius Envir Bull, 1992, 1(suppl): s48-53
16. Tang C, Lin J, Chen H. The repair effects of Kappa-selenocarrageenan on smokers with physiological damage. Fresenius Envir Bull, 1994, 3: 63-68
17. Yuan X, Tang C, DNA damage and repair in yeast (Saccharomyces cerevisiae) cells exposed to lead. J Environ Sci Health, 1999, A34: 1117-1128
18. Zhang XW, Liao HN, Tong TJ. Telomere shortening of MCF-7 cells caused by antisense telomerase cDNA. Acta Biochim Biophys Sin, 1999, 31: 527-530
19. Said AS, Sun JL, Chen Z, Huang JS, Zhang BS, Ren DM. Cloning and analysis of intron 3 of human telomerase reverse transcriptase (hTERT) gene. Acta Biochim Biophys Sin, 2000, 32: 359-363
20. Ercal N, Neal R, Treeratphan P, Lutz PM, Hammond TC, Dennery PA, Spitz DR. A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed fisher 344 rats. Arch Environ Contam Toxicol, 2000, 39: 251-256
21. Yoshida M, Tashiro H, Iwani K, Yasumoto K, Iwai K. Bioavailability of selenite, selenomethionine and selenocystine in rats with silver loading. Agric Biol Chem, 1983, 47: 807
22. Hu BZ, Xu Z, Hao W, Wang SQ. Study of the anti-preventive function of organic selenium on lead toxity. J Sanitat Res, 1998, 27: 229-232
23. Nehru B, Iyer A. Effect of selenium on lead induced neurotoxicity in different brain regions of adult rats. J Environ Pathol Toxicol Ecol, 1994, 13: 265-268
24. Othman AI, El Missiry MA. Role of Selenium against lead toxicity in male rats. J Biochem Molecul Toxicol, 1998, 12: 345-349