Effects of toxic extracts and purified borbotoxins from Prorocentrum borbonicum (Dinophyceae) on vertebrate neuromuscular junctions

Toxicon

Volumn 40, Issue 2, 2002, Pages 137-148

  Ten Hage, Loc ^a   Robillot, Cédric ^b   Turquet, Jean ^c   Le Gall, Frédéric ^d   Le Caer, Jean Pierre ^b   Bultel, Valérie ^a   Guyot, Michèle ^a   Molgó, Jordi ^d  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c Agence pour la Recherche et la Valorisation Marine   (France)

^d LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

Benthic dinoflagellates; Borbotoxin; Mass spectrometry; Neuromuscular junction; Prorocentrum borbonicum; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BORBOTOXIN; BUTANOL; NICOTINIC RECEPTOR; PALYTOXIN; SODIUM CHANNEL; TOXIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEATH; DINOFLAGELLATE; DYSPNEA; ELECTROPHYSIOLOGY; ENDPLATE POTENTIAL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEMBRANE STEADY POTENTIAL; MINIATURE ENDPLATE POTENTIAL; MOLECULAR WEIGHT; MOUSE; MUSCLE CONTRACTILITY; MUSCLE FIBER MEMBRANE; MUSCLE TWITCH; NERVE STIMULATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; SODIUM TRANSPORT; TOXICITY; ULTRAVIOLET RADIATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAPHRAGM; DINOFLAGELLIDA; ELECTROPHYSIOLOGY; FEMALE; INDIAN OCEAN; MALE; MARINE TOXINS; MEMBRANE POTENTIALS; MICE; MICROSCOPY, ELECTRON, SCANNING; MOTOR ENDPLATE; MUSCLE CONTRACTION; MUSCLE FIBERS; NEUROMUSCULAR JUNCTION; RANA ESCULENTA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE EXTRACTS;

EID: 0036027435     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00200-8     Document Type: Article

References (25)

1. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics
2. The ciguatera dinoflagellates
3. A new method for excitation-contraction uncoupling in frog skeletal muscle
4. Modulation of acetylcholine receptor channel by a polar component isolated from toxic Ostreopsis lenticularis extracts
5. Palytoxin. Recent electrophysiological and pharmacological evidence for several mechanisms of action
6. +-ATPase
7. Identification of DTX-4, a new water-soluble phosphatase inhibitor from the toxic dinoflagellate Prorocentrum lima
8. Two new water-soluble DSP toxin derivatives from the dinoflagellate Prorocentrum maculosum. Possible storage and excretion products
9. Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum
10. Ionspray mass spectrometry of ciguatoxin-1, maitotoxin-2 and -3, and related polyether toxins
11. HPLC/mass spectrometry and HPLC/MS/MS methods for the detection of multiple ciguatoxins
12. Okadaic acid production from the marine dinoflagellate Prorocentrum belizeanum Faust isolated from the Belizean coral reef ecosystem
13. Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima
14. Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning
15. Structures and configurations of ciguatoxin from the Moray eel Gymnothorax javanicus and its likely precursor from the dinoflagellate Gambierdiscus toxicus
16. Isolation of zooxanthellatoxins, novel vasoconstrictive substances from the zooxanthella Symbiodinium sp.
17. Nutrition and ecology of protozoa and algae
18. Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus
19. Okadaic acid production from the marine benthic dinoflagellate Prorocentrum arenarium Faust (Dinophyceae) isolated from Europa Island coral reef ecosystem (SW Indian Ocean)
20. Prorocentrum borbonicum sp. nov. (Dinophyceae), a new toxic benthic dinoflagellate from the southwestern Indian Ocean
21. Ciguatoxigenic dinoflagellates from the Caribbean Sea
22. Culture and toxicity of dinoflagellates from ciguatera endemic regions of the world
23. Prorocentrolide, a toxic nitrogenous macrocycle from a marine dinoflagellate, Prorocentrum lima
24. Palytoxin analogs from the dinoflagellate Ostreopsis siamensis
25. Occurrence of new type of shellfish poisoning in Japan and chemical properties of the toxin