Simulations to improve experimental designs for U-shaped dose-response modeling

Journal of Statistical Computation and Simulation

Volumn 72, Issue 9, 2002, Pages 737-746

  Hunt, Daniel ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Beta binomial; Developmental toxicity studies; Hormesis; Threshold; U shape

Indexed keywords

EID: 0036026576     PISSN: 00949655     EISSN: None     Source Type: Journal    
DOI: 10.1080/00949650214266     Document Type: Article

References (16)

1. Calabrese, E.J. (1987). The occurrence of chemically induced hormesis. Health Physics, 52(5), 531-541.
2. Chen, J.J. and Kodell, R.L. (1989). Quantitative risk assessment for teratological effects. Journal of the American Statistical Association, 84, 966-971.
3. Doull, J., Cattley, R., Elcombe, C., Lake, B.G., Swenberg, J., Wilkinsin, C., Williams, G. and van Gemert, M. (1999). A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new U.S. EPA risk assessment guidelines. Regulatory Toxicology and Pharmacology, 29(3), 327-357.
4. Gaylor, D. (1994). Biostatistical approaches to low level exposures. In: Calabrese, E.J. (Ed.), Biological Effects of Low Levels: Dose-response Relationships. Lewis Publishers, Boca Raton.
5. Goldsworthy, T. (1984). The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylamine administration. Carcinogenesis, 5(1), 67-71.
6. Nelder, J.A. and Mead, R. (1965). A simplex method for function minimization. Computer Journal, 7, 308-313.
7. Olsson, D.M. (1974). A sequential simplex program for solving minimization problems. Statistical Computer Programs, 6(1), 53-57.
8. Paul, S.R. (1982). Analysis of proportions of affected foetuses in teratological experiments. Biometrics, 38, 361-370.
9. Ryan, L. (1992). Quantitative risk assessment for developmental toxicity. Biometrics, 48, 163-174.
10. Schwartz, P., Gennings, C. and Chinchilli, V. (1995). Threshold models for combination data from reproductive and developmental experiments. Journal of the American Statistical Association, 90, 862-870.
11. Sielken, R.L. and Stevenson, D.E. (1998). Some implications for quantitative risk assessment if hormesis exists. Human and Experimental Toxicology, 17, 259-262.
12. Teeguarden, J.G., Dragan, Y. and Pitot, H.C. (2000). Hazard assessment of chemical carcinogens: The impact of hormesis. Journal of Applied Toxicology, 20, 113-120.
13. Tyl, R.W., Jones-Price, C., Marr, M.C. and Kimmel, C.A. (1983). Teratologic evaluation of diethylhexyl phthalate (CAS No. 117-81-7) in CD-1 mice, Final Study Report for NCTR/NTP Contract No. 222-80-2031 (C), NTIS No. PB85105674, National Technical Information Service, Springfield, VA.
14. USEPA. (1996). Proposed guidelines for carcinogen risk assessment; notice. Federal Register, 61, 79.
15. Williams, D.A. (1975). The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity. Biometrics, 31, 949-952.
16. Young, S.S. (1984). Exploration of the negative correlation between proliferative hepatocellular lesions and lymphoma in rats and mice-establishment and implications. Fundamental and Applied Toxicology, 4, 632-640.