The interleukin-6 -174promoter polymorphism is associated with long-term kidney allograft survival

Kidney International

Volumn 62, Issue 5, 2002, Pages 1824-1827

  Müller Steinhardt, Michael ^a,b   Härtel, Christoph ^a,b   Müller, Brigitte ^a,b   Kirchner, Holger ^a,b   Fricke, Lutz ^a,b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

Anti inflammatory; Genotyping; Host defense; Immunosuppression; Kidney graft survival; Pleiotropic cytokine; T helper cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GRAFT SURVIVAL; HLA MATCHING; HUMAN; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SURVIVAL TIME; ALLOTRANSPLANTATION; CAUCASIAN; CHRONIC KIDNEY FAILURE; FEMALE; GENETICS; KIDNEY TRANSPLANTATION; MALE; MORTALITY; PROMOTER REGION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE;

EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GRAFT SURVIVAL; HUMANS; INTERLEUKIN-6; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036025398     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00609.x     Document Type: Article

References (16)

1. Tilg H, Dinarello CA, Mier JW: IL-6 and APPs: Anti-inflammatory and immunosuppressive mediators. Immunol Today 18:428-432, 1997
2. Xing Z, Gauldie J, Cox G, et al: IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101:311-320, 1998
3. La Flamme AC, Pearce EJ: The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses. J Immunol 162:5829-5837, 1999
4. + T cells. J Exp Med 185:461-469, 1997
5. Fishman D, Faulds G, Jeffery R, et al: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369-1376, 1998
6. Marshall SE, McLaren AJ, McKinney EF, et al: Donor cytokine genotype influences the development of acute rejection after renal transplantation. Transplantation 71:469-476, 2001
7. Hahn AB, Kasten-Jolly JC, Constantino DM, et al: TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: Effects on renal allograft outcome. Transplantation 72:660-665, 2001
8. Opelz G, Mytilineos J, Scherer S, et al: Clinical implications of DNA typing in organ transplantation. The Collaborative Transplant Study. Transplant Proc 29:1524-1527, 1997
9. Asderakis A, Sankaran D, Dyer P, et al: Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: The cytokine effect on transplantation. Transplantation 71:674-677, 2001
10. Marshall SE, McLaren AJ, Haldar NA, et al: The impact of recipient cytokine genotype on acute rejection after renal transplantation. Transplantation 70:1485-1491, 2000
11. Poli F, Boschiero L, Giannoni F, et al: TNF-alpha IFN-gamma IL-6, IL-10, and TGF-beta1 gene polymorphisms in renal allografts. Transplant Proc 33:348-349, 2001
12. Reviron D, Dussol B, Andre M, et al: TNF-alpha and IL-6 gene polymorphism and rejection in kidney transplantation recipients. Transplant Proc 33:350-351, 2001
13. Sankaran D, Asderakis A, Ashraf S, et al: Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. Kidney Int 56:281-288, 1999
14. El Gamel A, Awad MR, Hasleton PS, et al: Transforming growth factor-beta (TGF-betal) genotype and lung allograft fibrosis. J Heart Lung Transplant 18:517-523, 1999
15. Hutchinson IV, Turner DM, Sankaran D, et al: Influence of cytokine genotypes on allograft rejection. Transplant Proc 30:862-863, 1998
16. Terry CF, Loukaci V, Green FR: Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275:18138-18144, 2000