Basiliximab in pediatric liver transplantation: A pharmacokinetic-derived dosing algorithm

Pediatric Transplantation

Volumn 6, Issue 3, 2002, Pages 224-230

  Kovarik, John M ^a,b   Gridelli, Bruno G ^c   Martin, Steven ^d   Rodeck, Burkhard ^e   Melter, Michael ^e   Dunn, Stephen P ^f   Merion, Robert M ^g   Tzakis, Andreas G ^h   Alonso, Estella ⁱ   Bucuvalas, John ^j   Sharp, Harvey ^k   Gerbeau, Christophe ^a,b   Chodoff, Lawrence ^a,b   Korn, Alexander ^a,b   Hall, Michael ^a,b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Ospedali Riuniti di Bergamo ^*

^c OSPEDALI RIUNITI   (Italy)

^d UNIVERSITY OF MONTREAL   (Canada)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

^g UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

ⁱ CHILDREN'S MEMORIAL HOSPITAL   (United States)

^j CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^k UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

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Author keywords

Basiliximab; Cyclosporin A; Immunosuppression; Liver transplantation; Monoclonal antibody; Pediatrics; Pharmacokinetics

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN A; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ANTIBODY; ANTIIDIOTYPIC ANTIBODY; BASILIXIMAB; HYBRID PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; MONOCLONAL ANTIBODY;

ADOLESCENT; ALGORITHM; ARTICLE; ASCITES FLUID; BODY SIZE; BODY SURFACE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE CALCULATION; DRUG CLEARANCE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEVER; GRAFT REJECTION; HUMAN; HYPERTENSION; INFANT; INFECTION; LIVER TRANSPLANTATION; MALE; MALIGNANT NEOPLASTIC DISEASE; MULTICENTER STUDY; ORGAN PERFUSION; PEDIATRIC SURGERY; SEPSIS; AREA UNDER THE CURVE; BIOSYNTHESIS; BLOOD; PRESCHOOL CHILD; PROSPECTIVE STUDY;

ADOLESCENT; ALGORITHMS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; AREA UNDER CURVE; CHILD; CHILD, PRESCHOOL; FEMALE; HUMAN; IMMUNOSUPPRESSIVE AGENTS; INFANT; INTERLEUKIN-2; LIVER TRANSPLANTATION; MALE; PROSPECTIVE STUDIES; HUMANS; RECOMBINANT FUSION PROTEINS;

EID: 0036022212     PISSN: 13973142     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3046.2002.01086.x     Document Type: Article

References (7)

1. Basiliximab (Simulect) reduces the rate and severity of acute rejection in adult liver transplant recipients
2. A population screen to identify demographic-clinical covariates of basiliximab in liver transplantation
3. Disposition and immunodynamics of basiliximab in liver allograft recipients
4. Disposition of basiliximab in de novo pediatric renal transplantation
5. 100 Consecutive liver transplants in infants and children: An 8-year experience
6. Liver transplantation in small babies
7. Oral tacrolimus (FK506) induction therapy in pediatric orthotopic liver transplantation