Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: Correlation with viral serotypes and clinical stages of liver disease

Journal of Medical Virology

Volumn 68, Issue 1, 2002, Pages 50-59

  Liu, Chun Jen ^a   Kao, Jia Horng ^a,b   Shau, Wen Yi ^b   Chen, Pei Jer ^a,b   Lai, Ming Yang ^a,b   Chen, Ding Shinn ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

a determinant; B cell epitope; T cell epitope

Indexed keywords

EPITOPE; VIRUS DNA; HEPATITIS B SURFACE ANTIGEN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CHRONIC HEPATITIS; CYTOTOXIC T LYMPHOCYTE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; CROSS-SECTIONAL STUDY; FEMALE; GENETIC VARIABILITY; GENETICS; LIVER TUMOR; MALE; MIDDLE AGED; MOLECULAR GENETICS; PATHOPHYSIOLOGY; SEROTYPING; VIROLOGY; VIRUS GENE;

HEPATITIS B VIRUS;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CROSS-SECTIONAL STUDIES; DNA, VIRAL; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; GENES, VIRAL; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SEROTYPING; VARIATION (GENETICS);

EID: 0036021198     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.10169     Document Type: Article

References (25)

1. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
2. Vaccine-induced escape mutant of hepatitis B virus
3. Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis
4. Mutation "hot spot" in HLA class Irestricted T-cell epitope on hepatitis B surface antigen in chronic carriers and hepatocellular carcinoma
5. Human hepatitis B virus mutants: Significance of molecular changes
6. Hepatitis B immunopathogenesis
7. Precore mutations and core clustering mutations in chronic hepatitis B virus infection
8. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection
9. Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis
10. Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan
11. Clinical relevance of hepatitis B viral mutations
12. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
13. Avoid false positive with PCR
14. Hepatitis B virus infection
15. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal
16. Licensed recombinant hepatitis B vaccines protect against infection with the prototype surface gene mutant of hepatitis B virus
17. Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus
18. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
19. Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen
20. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers
21. Surface gene variations of HBV: Scientific and medical relevance
22. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum
23. Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy
24. Effect of hepatitis B virus mutants on efficacy of vaccination
25. Molecular epidemiology and hepatitis B virus mutants