β2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease

Pharmacogenetics

Volumn 12, Issue 5, 2002, Pages 347-353

  Büscher, Rainer ^a   Eilmes, Katrin Jennifer ^a   Grasemann, Hartmut ^a   Torres, Brian ^a   Knauer, Nicola ^a   Sroka, Karin ^a   Insel, Paul A ^a   Ratjen, Felix ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

2 adrenoceptor; cAMP; CFTR; Cystic fibrosis; FEV1; Polymorphism

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; BRONCHODILATING AGENT; CYCLIC AMP; GLUTAMINE; GLYCINE; ISOLEUCINE; SALBUTAMOL; THREONINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CFTR PROTEIN, HUMAN; PRIMER DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ACTIVITY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC CODE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LUNG DISEASE; LUNG FUNCTION; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; RESPIRATORY AIRFLOW; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; AMINO ACID SUBSTITUTION; ENZYMOLOGY; GENETICS; HETEROZYGOTE; HOMOZYGOTE; LUNG; LUNG FUNCTION TEST; NUCLEOTIDE SEQUENCE; VITAL CAPACITY;

ADOLESCENT; ADRENERGIC BETA-AGONISTS; ADULT; ALLELES; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CHILD; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA PRIMERS; FEMALE; FORCED EXPIRATORY VOLUME; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LUNG; MALE; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY FUNCTION TESTS; VITAL CAPACITY;

EID: 0036020992     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200207000-00002     Document Type: Article

References (35)

1. Therapeutic approaches for cystic fibrosis: Memorandum from a joint WHO/ICF (M) A meeting
2. Frequency of CFTR gene mutations in males participating in an ICSI programme
3. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
4. Correlation between genotype and phenotype in patients with cystic fibrosis
5. Expression of delta F508 cystic fibrosis transmembrane conductance regulator protein and related chloride transport properties in the gallbladder epithelium from cystic fibrosis patients
6. Adrenergic receptors - Evolving concepts and clinical implications
7. Recent advances in asthma
8. Adenylate cyclase in leukocytes from patients with cystic fibrosis
9. Are lymphocyte beta-adrenoceptors altered in patients with cystic fibrosis?
10. 2-adrenergic receptor function
11. Human adrenoceptor polymorphisms: Evolving recognition of clinical importance
12. 2-adrenergic receptor in normal and asthmatic subjects
13. Amino-terminal polymorphisms of the human beta2-adrenergic receptor impart distinct agonist-promoted regulatory properties
14. 2-adrenoceptors
15. 2-adrenergic receptors
16. 2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in Whites and African Americans
17. Human beta2-adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta2-adrenoceptor function
18. 2-adrenoceptor variants with bronchial hyperresponsiveness
19. Genetic polymorphisms of the beta2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype
20. 2-adrenoceptor and response to albuterol in children with and without a history of wheezing
21. Lung volumes in healthy boys and girls 6-15 years of age
22. Lung volumes and forced ventilatory flows
23. 2-adrenoceptors. Accelerated restoration of β-adrenoceptor responsiveness by prednisone and ketotifen
24. Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
25. CFTR may play a role in regulated secretion by lymphocytes: A new hypothesis for the pathophysiology of cystic fibrosis
26. Genotype and phenotype in cystic fibrosis
27. HLA class II polymorphism in cystic fibrosis. A possible modifier of pulmonary phenotype
28. Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene
29. An alpha1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary outcome in cystic fibrosis
30. ΔF508 CFTR protein expression in tissues from patients with cystic fibrosis
31. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
32. Chloride conductance and genetic background modulate the cystic fibrosis phenotype of ΔF508 homozygous twins and siblings
33. Association of Glu 27 beta2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
34. Pharmacogenetics of relevant targets in asthma
35. Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice