Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues

Growth Factors

Volumn 20, Issue 2, 2002, Pages 71-80

  Nice, E C ^a   Domagala, T ^a   Fabri, L ^a   Nerrie, M ^a   Walker, F ^a   Jorissen, R N ^a   Burgess, A W ^a   Cui, D F ^b   Zhang, Y S ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

EGF; EGF receptor; Enzymic semisynthesis; Micropreparative HPLC; Structure function

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; CARBOXYPEPTIDASE C; DIPEPTIDE DERIVATIVE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR DERIVATIVE; ISOLEUCINE; LEUCINE; SYNTHETIC PEPTIDE; TRYPSIN; CARBOXYPEPTIDASE; DRUG DERIVATIVE; LIGAND; PEPTIDE; PPGB PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIGESTION; ENZYME SYNTHESIS; MALE; MICROANALYSIS; MITOGENESIS; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; VALIDATION PROCESS; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CELL STRAIN 3T3; CHEMISTRY; DOSE RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; MASS SPECTROMETRY; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME;

3T3 CELLS; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMAL; CARBOXYPEPTIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; HUMAN; KINETICS; LEUCINE; LIGANDS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRYPSIN; ANIMALS; CARBOXYPEPTIDASE C; HUMANS;

ANIMALIA; MURINAE;

EID: 0036020946     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190290015723     Document Type: Article

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