A convenient synthesis for some new pyrido [4′,3′:4,5]thieno[2,3-d]pyrimidines and related fused 1,2,4-triazolo and 1,3,4-thiadiazolo-derivatives

Phosphorus, Sulfur and Silicon and Related Elements

Volumn 177, Issue 5, 2002, Pages 1323-1336

  Ahmed, Essam Kh ^a  

^a El Minia University ^*  (Egypt)

Author keywords

Fused S, N heterocycles; Pyrido 4 ,3 :4,5 thieno 2,3 d pyrimidines; Pyrido 4 ,3 :4,5 thieno 2,3 d 1,2,4 triazolo 1,5 a pyrimidines; Pyrido 4 ,3 :4,5 thieno 2,3 d 1,3,4 thiadiazolo 3,2 a pyrimidines

Indexed keywords

DICARBOXYLIC ACID DERIVATIVE; DIETHYL (4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDIN 2 YL)THIOSEMICARBAZIDE 3,6 DICARBOXYLATE; DIETHYL 2 [[[(2 CHLOROPHENYL)AMINO]CARBOTHIOYL]AMINO] 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3,6 DICARBOXYLATE; DIETHYL 2 [[[(4 CHLOROPHENYL)AMINO]CARBOTHIOYL]AMINO] 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3,6 DICARBOXYLATE; DIETHYL 2 [[[(4 METHOXYPHENYL)AMINO]CARBOTHIOYL]AMINO] 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3,6 DICARBOXYLATE; DIETHYL 2 [[[(4 TOLYL)AMINO]CARBOTHIOYL]AMINO] 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3,6 DICARBOXYLATE; DIETHYL 2 [[[(PHENYL)AMINO]CARBOTHIOYL]AMINO] 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3,6 DICARBOXYLATE; ETHYL 10 OXO 8,9 DIHYDRO 10H PYRIDO[4',3':4,5]THIENO[2,3 D][1,3,4]THIADIAZOLO[3,2 A]PYRIMIDINE 7(6H) CARBOXYLATE; ETHYL 2 METHYL 10 OXO 8,9 DIHYDRO 10H PYRIDO[4',3':4,5]THIENO[2,3 D][1,3,4]THIADIAZOLO[3,2 A]PYRIMIDINE 7(6H) CARBOXYLATE; ETHYL 2 PHENYL 10 OXO 8,9 DIHYDRO 10H PYRIDO[4',3':4,5]THIENO[2,3 D][1,3,4]THIADIAZOLO[3,2 A]PYRIMIDINE 7(6H) CARBOXYLATE; ETHYL 3 AMINO 2 (METHYLTHIO) 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2 HYDRAZINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2 PHENYLAMINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2,2 CHLOROPHENYLAMINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2,4 CHLOROPHENYLAMINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2,4 METHOXYPHENYLAMINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 2,4 TOLYLAMINO 4 OXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 AMINO 4 OXO 2 THIOXO 1,3,4,5,6,8 HEXAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(2H) CARBOXYLATE; ETHYL 3 AMINO 4 OXO 2 THIOXO 3,5,6,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE 7(4H) CARBOXYLATE; ETHYL 3 ETHOXYMETHYLENEAMINO 10 OXO 3,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[3,2 D][1,24]TRIAZOLO[1,5 A]PYRIMIDINE 7(6H) CARBOXYLATE; ETHYL 3 PHENYL 10 OXO 6,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 7 CARBOXYLATE; ETHYL 3,2 CHLOROPHENYL 10 OXO 6,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 7 CARBOXYLATE; ETHYL 3,4 CHLOROPHENYL 10 OXO 6,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 7 CARBOXYLATE; ETHYL 3,4 METHOXYPHENYL 10 OXO 6,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 7 CARBOXYLATE; ETHYL 3,4 TOLYL 10 OXO 6,8,9,10 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 7 CARBOXYLATE; ETHYL 4 ETHOXYMETHYLENEAMINO 5 OXO 4,5,6,9 TETRAHYDROPYRIDO[4',3':4,5]THIENO[3,2 E][1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 8(7H) CARBOXYLATE; PYRIMIDINE DERIVATIVE; THIADIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALYTIC METHOD; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0036018056     PISSN: 10426507     EISSN: None     Source Type: Journal    
DOI: 10.1080/10426500211720     Document Type: Article

References (23)

1. C. G. Dave, P. R. Shah, K. C. Dave, and V. J. Patel, J. Indian Chem. Soc., 66, 48 (1989).
2. E. Bousquet, G. Romero, F. Guerrera, A. Caruso, and M. A. Roxas, Farmaco Ed. Sci., 40, 869 (1985).
3. E. Bousquet, F. Guerrera, N. A. Siracusa, A. Caruso, and M. A. Roxas, Farmaco Ed. Sci., 39, 110 (1984).
4. H. Vieweg, S. Leistner, G. Wagner, N. Boehm, U. Krasset, R. Grupe, D. Lohmann, and G. Loban, East Ger. Pat. DD 257,830 (1988); Chem. Abstr., 110, 95262p (1989).
5. H. Vieweg, S. Leistner, G. Wagner, N. Boehm, U. Krasset, R. Grupe, D. Lohmann, and G. Loban, East Ger. Pat. DD 257,830 (1988); Chem. Abstr., 110, 95262p (1989).
6. H. Vieweg, S. Leistner, G. Wagner, N. Boehm, U. Krasset, R. Grupe, D. Lohmann, and G. Loban; East Ger. Pat. DD 258,234 (1988); Chem. Abstr., 110, 95263p (1989).
7. H. Vieweg, S. Leistner, G. Wagner, N. Boehm, U. Krasset, R. Grupe, D. Lohmann, and G. Loban; East Ger. Pat. DD 258,234 (1988); Chem. Abstr., 110, 95263p (1989).
8. E. F. Elslager, P. W. Jacob, and M. Leslio, J. Heterocyclic Chem., 9, 775 (1972).
9. M. Chaykovsky, M. Lin, A. Rosowsky, and E. J. Modest, J. Med. Chem., 10, 188 (1973).
10. S. Leistner, G. Wagner, M. Guetscharo, and E. Glusa, Pharmazie, 41, 54 (1986).
11. G. D. Madding and M. D. Thompson, J. Heterocyclic Chem., 24, 581 (1987).
12. C. J. Shishoo, M. B. Devani, and V. S. Bhadti, Indian Pat. 151, 456 (1983); Chem. Abstr, 100, 209858 (1984).
13. C. J. Shishoo, M. B. Devani, and V. S. Bhadti, Indian Pat. 151, 456 (1983); Chem. Abstr, 100, 209858 (1984).
14. M. Dobosz, A. Pachuta, and J. Rekas, Acta Polon. Pharm., 50, 225 (1993).
15. M. Dobosz, J. Rekas, and A. Pachuta, Acta Polon. Pharm., 46, 40 (1989).
16. Lubrizol Corp, U.S. Pat. 4.246.126 (1981); Chem. Abstr., 94, 142505h (1981).
17. Lubrizol Corp, U.S. Pat. 4.246.126 (1981); Chem. Abstr., 94, 142505h (1981).
18. E. Kh. Ahmed, A. M. N. Gohar, and M. A. Ameen, Pharmazie, 55(1), 31 (2000).
19. E. Kh. Ahmed, U. Sensfuss, and W. D. Habicher, J. Heterocyclic Chem., 36, 1119, (1999).
20. E. Kh. Ahmed, J. Frohlich, and F. Sauter, Collect. Czech. Chem. Commun., 61, 147 (1996).
21. F. Sauter, J. Frohlich, and E. Kh. Ahmed, Monatsh. Chem., 127, 319 (1996).
22. E. Kh. Ahmed, Monatsh Chem., 126, 953 (1995).
23. F. Sauter, U. Jordis, J. Frohlich, K. Gewald, F. Grohmann, and E. Kh. Ahmed, ACH-Models in Chemistry, 131, 489 (1994).