Inhibition of the mitochondrial respiratory chain by phenylalanine in rat cerebral cortex

Neurochemical Research

Volumn 27, Issue 5, 2002, Pages 353-357

  Rech, Virginia Cielo ^a   Feksa, Luciane Rosa ^a   Dutra Filho, Carlos Severo ^a   De Souza Wyse, Angela Terezinha ^a   Wajner, Moacir ^a   Wannmacher, Clovis Milton Duval ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Phenylalanine; Phenylketonuria; Respiratory chain

Indexed keywords

PHENYLALANINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; CONTROLLED STUDY; ELECTRON TRANSPORT; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; INBORN ERROR OF METABOLISM; MITOCHONDRIAL RESPIRATION; NEUROTOXICITY; NONHUMAN; PHENYLKETONURIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RESPIRATORY CHAIN; ANIMAL; DRUG EFFECT; METABOLISM; MITOCHONDRION; WISTAR RAT;

ANIMAL; CEREBRAL CORTEX; ELECTRON TRANSPORT; MITOCHONDRIA; PHENYLALANINE; PHENYLKETONURIAS; RATS; RATS, WISTAR; ANIMALS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0036014970     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015529511664     Document Type: Article

References (34)

1. Hyperphenylalaninemia: Phenylalanine hydroxylase deficiency
2. Effect of phenylalanine, p-chlorophenylalanine and α-methylphenylalanine on glucose uptake in vitro by the brain of young rats
3. +-ATPase activity in the synaptic plasma membrane from the cerebral cortex of rats subjected to chemically induced phenylketonuria
4. 32P into cytoskeletal cerebral proteins
5. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria
6. Morphologic and histoanatomic observations of the brain in untreated human phenylketonuria
7. Disorders related to mitochondrial membranes: Pathology of the respiratory chain and neurodegeneration
8. Mitochondrial diseases in man and mouse
9. Oxygen activation and the conservation of energy in cell respiration
10. Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex
11. Differencial investigation of the capacity of succinate oxidation in human skeletal muscle
12. Biochemical and molecular investigations in respiratory chain deficiencies
13. Mitochondrial complex I deficiency in Parkinson's disease
14. Localization of endogenous ATPases at the nerve terminal
15. Protein measurement with the Folin phenol reagent
16. Evidence for the existence of two classes of sulfhydryl groups essential for membrane-bound succinate dehydrogenase activity
17. Experimental phenylketonuria provokes oxidative stress in rat brain
18. Antioxidant status in hyperphenylalaninemia
19. Inhibition of human brain pyruvate kinase and hexokinase by phenylalanine and phenylpiruvate: Possible relevance to phenylketonuric brain damage
20. Neuropathological aspects of cytochrome c oxidase deficiency
21. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
22. +) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase
23. 2+ release: An intimate connection
24. Mitochondrial function: A determinant of recovery or death in cell response to injury
25. NADH and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
26. An analysis of the role of coenzyme Q in free radical generation and as an anti-oxidant
27. Human complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect
28. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
29. Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: Relevance to Parkinson's disease
30. +) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
31. Energetics in the pathogenesis of neurodegenerative diseases
32. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
33. Neurotoxicity of glutamate uptake inhibition in vivo: Correlation with succinate dehydrogenase activity and prevention by energy substrates
34. Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation