Simple method of methylation for gas chromatographic analysis of S-benzyl-N-acetylcysteine, a metabolite of toluene, in human urine

Journal of Analytical Toxicology

Volumn 26, Issue 4, 2002, Pages 189-192

  Takahashi, S ^a   Uezono, T ^b   Akane, A ^c   Kimura, K ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; BENZYL N ACETYLCYSTEINE; DIAZOMETHANE; HYDROCHLORIC ACID; METHANOL; N ACETYL S BENZYLCYSTEINE; ORGANIC SOLVENT; PHENETHYL N ACETYLCYSTEINE; TOLUENE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; DRUG DERIVATIVE; S BENZYL N ACETYL L CYSTEINE; S-BENZYL-N-ACETYL-L-CYSTEINE;

ACCURACY; ACIDIFICATION; ARTICLE; CALIBRATION; DERIVATIZATION; EXPOSURE; GAS CHROMATOGRAPHY; METHYLATION; URINALYSIS; CHEMISTRY; COMPARATIVE STUDY; HUMAN; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SUBSTANCE ABUSE; URINE; VALIDATION STUDY;

ACETYLCYSTEINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; METHANOL; METHYLATION; REPRODUCIBILITY OF RESULTS; SUBSTANCE ABUSE DETECTION; TOLUENE;

EID: 0036014543     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/26.4.189     Document Type: Article

References (6)

1. Analysis of mercapturic acids as a tool in biotransformation, biomonitoring and toxicological studies
2. Detection and measurement of S-benzyl-N-acetylcysteine in urine of toluene sniffers using capillary gas chromatography
3. Determination of S-benzyl-N-acetyl-L-cysteine by gas chromatography/mass spectrometry as a new marker of toluene exposure
4. Sensitive gas chromatographic method for determination of mercapturic acids in human urine
5. S-p-Toluylmercapturic acid in the urine of workers exposed to toluene
6. Gas chromatographic method for the simultaneous determination of S-toluylmercapturic acid and S-phenylmercapturic acid in human urine