Expression of ets-related transcription factors and matrix metalloproteinase genes in human breast cancer cells

Breast Cancer Research and Treatment

Volumn 72, Issue 3, 2002, Pages 227-232

  Barrett, Jane M ^a   Puglia, Mark A ^a   Singh, Gurmit ^a   Tozer, Richard G ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Breast cancer; Ets proteins; Matrix metalloproteinases

Indexed keywords

ETS1 PROTEIN, HUMAN; GELATINASE B; MATRIX METALLOPROTEINASE; ONCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETS 1; COLLAGENASE 3; GELATINASE A; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 16; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR ERM; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR PEA3; UNCLASSIFIED DRUG;

ARTICLE; BREAST TUMOR; CELL CULTURE; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; BREAST CANCER; CANCER INVASION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; GELATINASE B; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0036010913     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014993006190     Document Type: Article

References (34)

1. The Ets family of transcription factors
2. An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16:21) chromosomal translocation
3. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
4. ETS1 gene in myelodysplastic syndrome with chromosome change at 11q23
5. PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas
6. ESX: A structurally unique Ets overexpressed early during human breast tumorigenesis
7. Molecular characterization of the ets-related human transcription factor ER81
8. Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells
9. Ets-related protein E1AF can activate three different matrix metalloproteinase gene promoters
10. A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells
11. Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential
12. Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras transformed murine fibroblasts
13. Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo
14. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
15. Immunoassays of the metalloproteinase (MMP-2) and tissue inhibitor of metalloproteinase (TIMPS 1 and 2) levels in noninvasive and metastatic PC-3 clones: Effects taxol
16. Expression of activated gelatinase in human breast carcinoma
17. Type IV collagenase (Mr 72,000) expression in human prostate: Benign and malignant tissue
18. Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma
19. Expression of 72 kDa type IV collagenase (gelatinase A) in benign and malignant ovarian tumours
20. Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours
21. Levels of matrix metalloproteinase in bladder cancer correlate with tumor grade and invasion
22. Matrix metalloproteinase gene expression
23. Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription
24. Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity
25. Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MTI-MMP expression
26. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
27. 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′ flanking region
28. Electrophoretic analysis of plasm inogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates
29. Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines
30. Regulation of urokinase-type plasminogen activator gene transcription by Macrophage Colony-Stimulating Factor
31. The expression of an Ets1 transcription factor lacking its activation domain decreases uPA proteolytic activity and cell motility, and impairs normal tubulogenesis and cancerous scattering in mammary epithelial cells
32. Ets-1 positively regulates expression of urokinase-type plasminogen activator (uPA) and invasiveness of astrocytic tumors
33. Ets-1 transcription factor-mediated urokinase-type plasminogen activator expression and invasion in glioma cells stimulated by serum and basic fibroblast growth factors