Methods for compound selection focused on hits and application in drug discovery

Journal of Molecular Graphics and Modelling

Volumn 20, Issue 6, 2002, Pages 439-446

  Stahura, Florence L ^a   Xue, Ling ^a   Godden, Jeffrey W ^a   Bajorath, Jürgen ^a,b  

^a ALBANY MOLECULAR RESEARCH INC   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Database mining; Docking; Drug discovery; Focused libraries; Molecular fingerprints; Protein protein interaction; Virtual screening

Indexed keywords

DRUG INTERACTIONS; LEAD COMPOUNDS; PROTEINS; SCREENING;

VIRTUAL SCREENING;

DRUG PRODUCTS;

COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; CONFERENCE PAPER; DATA BASE; DRUG DESIGN; DRUG SCREENING; EXPERIMENTAL DESIGN; METHODOLOGY; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICS; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; FACTUAL DATABASE; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

MEMBRANE PROTEIN; PEPTIDE LIBRARY; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL X;

BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BINDING SITES; DATABASES, FACTUAL; DRUG DESIGN; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036010703     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(01)00145-0     Document Type: Conference Paper

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