A practical synthesis and biological evaluation of 9-halogenated PGF analogues

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 6, 2002, Pages 1883-1894

  Tani, Kousuke ^a   Naganawa, Atsushi ^a   Ishida, Akiharu ^a   Egashira, Hiromu ^a   Odagaki, Yoshihiko ^a   Miyazaki, Toru ^a   Hasegawa, Tomoyuki ^a   Kawanaka, Yasufumi ^a   Sagawa, Kenji ^a   Harada, Hiroyuki ^a   Ogawa, Mikio ^a   Maruyama, Takayuki ^a   Nakai, Hisao ^a   Ohuchida, Shuichi ^a   Kondo, Kigen ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZENESULFONYL 3 (TETRAHYDRO 2H PYRAN 2 YL)OXY 4,4 TRIMETHYLENEHEXANE; 4,4 TRIMETHYLENE 2 HEXEN 1 OL; 7 [5 CHLORO 2 FORMYL 3 (TETRAHYDRO 2H PYRAN 2 YLOXY)CYCLOPENTYL]HEPT 5 ENOIC ACID METHYL ESTER; 9 DEOXY 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; 9 DEOXY 9ALPHA CHLORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; 9 DEOXY 9BETA BROMO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; 9 DEOXY 9BETA CHLORO 13,14 DIHYDRO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; 9 DEOXY 9BETA CHLORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F1; 9 DEOXY 9BETA CHLORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; 9 DEOXY 9BETA CHLORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 5,6,13,14 TETRAHYDRO 20 NORPROSTAGLANDIN F2; 9 DEOXY 9BETA FLUORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE 20 NORPROSTAGLANDIN F2; ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; FUNCTIONAL GROUP; HALIDE; LYSINE; PROSTAGLANDIN DERIVATIVE; SODIUM CHLORIDE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; CYCLIC AMP; HALOGEN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN F;

AGONIST; ANIMAL CELL; ARTICLE; ASYMMETRIC SYNTHESIS; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; EPOXIDATION; NONHUMAN; OPTICAL ROTATION; X RAY ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CONFORMATION; DRUG EFFECT; HAMSTER; METABOLISM; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

DRYAS IULIA;

ANIMALS; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HALOGENS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROSTAGLANDINS F, SYNTHETIC; RECEPTORS, PROSTAGLANDIN E; SECOND MESSENGER SYSTEMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036009886     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00008-1     Document Type: Article

References (15)