Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells

Journal of Experimental Therapeutics and Oncology

Volumn 2, Issue 2, 2002, Pages 85-92

  Berkovic, Dinko ^a   Sievers, Sabine ^a   Haase, Detlef ^a   Fleer, Eduard A M ^a   Binder, Claudia ^a  

^a Klinik Maria Hilf   (Germany)

Author keywords

Alkylphosphocholines; Etherlipid analogues; Hexadecylphosphocholine; Phospholipid metabolism

Indexed keywords

MILTEFOSINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; ANTINEOPLASTIC AGENT; CHOLINE; DRUG DERIVATIVE; PHOSPHORYLCHOLINE; SERINE;

ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPOGENESIS; LYMPHOMA CELL; PRIORITY JOURNAL; RAJI CELL; CELL CULTURE; DRUG RESISTANCE; LYMPHOMA; METABOLISM;

ANTINEOPLASTIC AGENTS; CHOLINE; DRUG RESISTANCE, NEOPLASM; HUMAN; LYMPHOMA; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; PHOSPHORYLCHOLINE; SERINE; TUMOR CELLS, CULTURED; HUMANS;

EID: 0036009622     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1359-4117.2002.01014.x     Document Type: Article

References (36)

1. Etherlipid derivatives: Antineoplastic activities in vitro and structure-relationship
2. Cytotoxic activity of lysophosphatidylcholine analogues on human lymphoma Raji cells
3. Characterization of the antitumor activity of hexadecylphosphocholine
4. Phospholipid analogue hexadecylphosphocholine inhibits proliferation and phosphatidylcholine biosynthesis of human epidermal keratinocytes in vitro
5. Cytotoxicity of alkyllysophospholipids; derivatives and low alkyl-cleavage enzyme activities in rat brain tumor cells
6. Hexadecylphosphocholine (D18506) in the topical treatment of skin metastases: A phase I trial
7. Hexadecylphosphocholine in the treatment of skin metastasis in breast cancer patients
8. Phase II trial of orally administered miltefosine in advanced colorectal cancer
9. Phase II study of daily oral hexadecylphosphocholine in advanced colorectal cancer
10. Daily oral miltefosine (hexadecylphosphocholine) in patients with advanced non small cell lung cancer. A phase II study
11. Topical application of hexadecylphosphocholine in patients with cutaneous lymphomas
12. The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in leukemic cells
13. The antineoplastic activity of hexadecylphosphocholine is associated with tumor cell differentiation
14. Effects of neoplastic phospholipids on parameters of cell differentiation in U937 cells
15. Antiinvasive activity of hexadecylphosphocholine in vitro
16. Hexadecylphosphocholine-mediated enhancement of T-cell responses to interleukin 2
17. Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells
18. Effects of hexa-decylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells
19. Inhibition of protein kinase C (sodium plus potassium) activated adenosine triphosphatase and sodium pump by synthetic phospholipid analogues
20. Selective inhibitation of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues
21. Hexadecylphosphocholine inhibits phosphatidylinositol and phosphatidylcholine specific phospholipase C in human leukemia cells
22. Differential regulation of phospholipase A2 in human leukemia cells by the etherphospholipid analogue hexadecylphosphocholine
23. Hexadecylphosphocholine inhibits translocation of CTP: Cholinephosphate-cytidylyltranferase in Madin-Darby canine kidney cells
24. Alkyllysophospholipids activate-the SAPK/JNK pathway and enhance radiation-induced apoptosis
25. Changes in cellular lipid synthesis of normal and neoplastic cells during cytolysis induced by alkyl lysophospholipid analogues
26. Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells
27. The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine synthesis in Madin-Darby canine kidney cells
28. Induction of resistance to hexadecylphosphocholine in the highly sensitive human epidermoid tumour cell line KB
29. Induction of resistance in the leukemia cell line HL 60 towards hexadecylphosphocholine and other ether phospholipid analogues
30. Expression of two 50 kDa proteins is associated with sensitivity towards etherlipid analogues in the human leukemia cell line HL60
31. Bcl- 2 plays a key role instead of mdr1 in the resistance to hexadecylphosphocholine in human epidermoid tumor cell line KB
32. Inhibition of cellular transport systems by alkyl phospholipid analogues in HL60 human leukemic cells
33. Phospholipid metabolism and cell signalling
34. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog hexadecylphosphocholine
35. Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G 1 arrest but not apoptosis
36. Multiplication and death type of leukemia cell lines exposed to very long-chain polyunsaturated fatty acids