Supercritical CO2 fluid radiochromatography system used to purify [11C]toluene for PET

Nuclear Medicine and Biology

Volumn 29, Issue 3, 2002, Pages 351-357

  Muller, Ryan D ^a   Ferrieri, Richard A ^b   Gerasimov, Madina ^b   Garza, Victor ^b  

^a The College of William and Mary   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Inhalants; PET; Substance abuse; Supercritical fluid

Indexed keywords

CARBON DIOXIDE; CYCLODEXTRIN; TOLUENE C 11; TRACER; UNCLASSIFIED DRUG; VOLATILE AGENT; RADIOPHARMACEUTICAL AGENT; SOLVENT; TOLUENE;

ANALYTIC METHOD; ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DESORPTION; DEVICE; DRUG FORMULATION; DRUG PURIFICATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; QUANTITATIVE ANALYSIS; RADIOCHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE DEPENDENCE; VALIDATION PROCESS; CHEMISTRY; GAS CHROMATOGRAPHY; ISOLATION AND PURIFICATION; REPRODUCIBILITY; TEMPERATURE; ULTRAVIOLET SPECTROPHOTOMETRY;

CARBON DIOXIDE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAME IONIZATION; ISOTOPE LABELING; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE; TOLUENE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036009491     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00284-6     Document Type: Article

References (35)

1. Inhalant use in the United States
2. Student's use of marijuana, other illicit drugs and cigarettes continue to rise in 1995
3. The epidemiology of adolescent inhalant drug involvement
4. Organic solvent neurotoxicity. Facts and research needs
5. Behavioral methods and organic solvents: Questions and consequences
6. Neurobehavioral effects of occupational exposure to low-level organic solvents among Taiwanese workers in paint factories
7. Changes in the peripheral blood of workers with occupational exposure to aromatic hydrocarbons
8. Toluene levels in blood and brain of rats during and after respiratory exposure
9. Toluene blood level following subcutaneous injection of toluene in the rat
10. Toluene levels in blood and brain of rats as a function of toluene level in inspired air
11. Whole-body autoradiography and allied tracer techniques in distribution and elimination studies of some organic solvents: Benzene, toluene, xylene, styrene, methylene chloride, chloroform, carbon tetrachloride and trichloroethylene
12. Experimental estimation of addictive potential of a mixture of organic solvents
13. Behavioral toxicology of carbon disulfide and toluene
14. Diagnostic concordance of DSM-III-R, DSM-IV and ICD-10 inhalant use disorders
15. Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes
16. Neuronal bases of solvent abuse
17. Toluene inhalation produces regionally specific changes in extracellular dopamine
18. The synthesis of aliphatic and aromatic hydrocarbons containing methyl groups labeled with carbon-11
19. 3-labeled PET tracers
20. 11C-toluene
21. Organic chemistry in supercritical fluids
22. Advances with supercritical fluids
23. Trends in techniques for the extraction of drugs and pesticides from biological specimens prior to chromatographic separation and detection
24. Supercritical fluids in separation science-the dreams, the reality and the future
25. Progress in packed column supercritical fluid chromatography: Materials and methods
26. 11C-labeled guanidines in supercritical ammonia
27. Investigation of acetonitrile solvent cluster formation in supercritical carbon dioxide, and its impact on microscale syntheses of carbon-11 labeled radiotracers for PET
28. Studies in linear restrictors and analyte collection via solvent trapping after supercritical fluid extraction
29. Restrictor plugging in off-line supercritical fluid extraction of environmental samples: Microscopic, chemical and spectroscopic evaluations
30. Trapping techniques in supercritical fluid extraction
31. Phase equilibria for supercritical fluid process design
32. 2 by on-line flame ionization detection
33. Pharmacokinetics and safety of a 7-day administration of intravenous itraconazole followed by a 14-day administration of intrconazole oral solution in patients with hematological malignancy