Mutation of the herpes simplex virus 1 KOS UL45 gene reveals dose dependent effects on central nervous system growth

Archives of Virology

Volumn 147, Issue 3, 2002, Pages 519-532

  Visalli, R J ^a   Brandt, C R ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; DNA VIRUSES; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

UL45 PROTEIN, HERPES SIMPLEX VIRUS TYPE 1; VIRUS PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BRAIN; CERCOPITHECUS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; MORTALITY; MOUSE; MUTATION; PATHOGENICITY; PATHOPHYSIOLOGY; VERO CELL; VIROLOGY; VIRULENCE; VIRUS REPLICATION;

ANIMALS; BRAIN; CERCOPITHECUS AETHIOPS; ENCEPHALITIS, HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; MICE; MICE, INBRED BALB C; MUTATION; VERO CELLS; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 0036008610     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050200004     Document Type: Article

References (41)

1. The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture
2. Evidence for an interaction of herpes simplex virus with chondroitin sulfate proteoglycans during infection
3. Mixed infection with herpes simplex virus type 1 generates recombinants with increased ocular and neurovirulence
4. The herpes simplex virus ribonucleotide reductase is required for ocular virulence
5. The left border of the genomic inversion of pseudorabies virus contains genes homologous to the UL46 and UL47 genes of herpes simplex virus type 1, but no UL45 gene
6. A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type I
7. Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target
8. Mapping of herpes simplex virus-I neurovirulence to γl-34.5, a gene nonessential for growth in culture
9. Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence
10. Hydroxylamine mutagenesis of HSV DNA and DNA fragments: Introduction of mutations into selected regions of the viral genome
11. A herpes simplex virus type 1 mutant containing a deletion within immediate early gene 1 is latency-competent in mice
12. Herpes simplex virus 2 UL45 is a type II membrane protein
13. The complete DNA sequence of varicella-zoster virus
14. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis
15. Construction and characterization of herpes simplex virus type 1 mutants with defined lesions in immediate early gene 1
16. Comparison of DNA facilitators in the uptake and intracellular fate of infectious herpes simplex virus type 2 DNA
17. Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: Characterization of an ICP6 deletion mutant
18. A herpes simplex type 1 ICP0 deletion mutant demonstrates diminished pathogenicity during acute ocular infection in different host animals
19. A new technique for the assay of infectivity of human adenovirus 5 DNA
20. Herpes simplex virus stromal keratitis is not titer-dependent and does not correlate with neurovirulence
21. The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion
22. Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B
23. Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo
24. Characterization of the UL10 gene product of herpes simplex virus type 1 and investigation of its role in vivo
25. DNA sequence and transcriptional analyses of the region of the equine herpesvirus type 1 Kentucky A strain genome encoding glycoprotein C
26. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
27. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus I
28. Elimination of UL56 gene by insertion of lacZ cassette between nucleotide position 116030 to 121753 of the herpes simplex virus type 1 genome abrogates intraperitoneal pathogenicity in tree shrews and mice
29. Computation of binomial probabilities
30. Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1
31. Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate early protein ICP-4
32. Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw 110
33. HSV molecular biology: General aspects of herpes simplex virus molecular biology
34. The herpes simplex virus type 2 (HG52) variant JH2604 has a 1488 bp deletion which eliminates neurovirulence in mice
35. Electrophoretic transfer of proteins from poly-acrylamide gels to nitrocellulose sheets: Procedure and some applications
36. The HSV-1 UL45 gene product is not required for growth in Vero cells
37. The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion
38. Herpes simplex genes: The blueprint of a successful human pathogen
39. The pathogenicity of ribonucleotide reductase null mutants of herpes simplex virus type 1 in mice