FcγR receptors activate MAP kinase and up-regulate the cyclooxygenase pathway without increasing arachidonic acid release in monocytic cells

European Journal of Immunology

Volumn 32, Issue 2, 2002, Pages 383-392

  Fernández, Nieves ^a   Renedo, Marta ^a   Sánchez Crespo, Mariano ^a,b  

^a Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Fc receptor; Inflammation; Lipid mediator; Protein kinase

Indexed keywords

ARACHIDONIC ACID; CHEMOKINE; CYCLOOXYGENASE 2; FC RECEPTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; PROTEIN P42; RECEPTOR SUBTYPE; AUTACOID; CROSS LINKING REAGENT; DNA BINDING PROTEIN; I KAPPA B; ISOENZYME; MEMBRANE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PTGS2 PROTEIN, HUMAN;

ANTIGEN ANTIBODY COMPLEX; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; BIOSYNTHESIS; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; UPREGULATION;

ARACHIDONIC ACID; BASE SEQUENCE; CELL LINE; CHEMOKINE CCL2; CROSS-LINKING REAGENTS; CYCLOOXYGENASE 2; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MONOCYTES; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, IGG; RNA, MESSENGER; UP-REGULATION;

EID: 0036008487     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200202)32:2<383::AID-IMMU383>3.0.CO;2-9     Document Type: Article

References (45)

1. Fc receptors initiate the Arthus reaction: Redefining the inflammatory cascade
2. Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice
3. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis
4. Fc receptors: Rubor redux
5. The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in a rat peritoneal macrophages is triggered by Fcγ receptor activation: Study of the signaling mechanism
6. Stimulation of Fcγ receptors in rat peritoneal macrophages induces the expression of nitric oxide synthase and chemokines by mechanisms showing different sensitivities to antioxidants and nitric oxide donors
7. Stimulation of FcγR receptors induces monocyte chemoattractant protein-1 (MCP-1) in the human monocytic cell line THP-1 by a mechanism involving lκB-α degradation and formation of p50/p65 NF-κB/Rel complexes
8. The FcγRI receptor signals through the activation of hck and MAP kinase
9. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages
10. FcγR cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: Role for p42-MAP kinase in FcγR-stimulated TNF-α synthesis
11. A Comparison of mediators released or generated by IFN-γ-treated human mast cells following aggregation of FcγRI or FcRI
12. syk
13. FcγRIIA exogenously expressed in HeLa cells activates the mitogen-activated protein kinase cascade by a mechanism dependent on the endogenous expression of the protein tyrosine kinase Syk
14. The human monocyte-like cell line THP-1 expresses FcγRI and FcγRII
15. 2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules
16. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or lgE/antigen
17. 2 pathway by FcεRI is not shared by a G-protein-coupled receptor
18. Functional contributions of the FcεRlα and FcεRlγ subunit domains in FcεRI-mediated signaling in mast cells
19. Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids
20. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
21. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor-α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
22. Cross-linking of both FcγRI and FcγRII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-FcγR interactions. Functional activation of FcγRII by treatment with proteases or neuraminidase
23. Fcγ receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of ras
24. Association of MEK1 with p21 ras. GMPPNP is dependent on B-Raf
25. 2 phosphorylation and eicosanoid production by colony-stimulating factor 1
26. 2 and transactivation of cyclooxygenase-2
27. Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
28. Phosphorylation of Raf by ceramide-activated protein kinase
29. Tumor necrosis factor-α rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf- 1-independent fashion in mouse macrophages
30. 2 regulation
31. 2 is phosphorylated and activated by MAP kinase
32. 2
33. 2 and the distinct transcriptional programs of astrocytoma cells
34. 2 and cyclooxygenase-2 in human squamous carcinoma A431 cells
35. 2 synthesis in mouse osteoblasts cultured with interleukin-1
36. A novel signaling mechanism between gas and blood compartments of the lung
37. Cross-linking of Fcγ receptor I (FcγRI) and receptor II (FcγRII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase
38. 2+ response in human neutrophils
39. 2+ transients
40. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells
41. E-type prostaglandins enhance local oedema formation and neutrophil accumulation but suppress eosinophil accumulation in guinea-pig skin
42. Local administration of transcription factor decoy oligonucleotides to nuclear factor-κB prevents carrageenin-induced inflammation in rat hind paw
43. Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation
44. Human cyclooxygenase-2 cDNA
45. 2 from plasma of patients with septic shock is associated with high-density lipoproteins and C3 anaphylatoxin: Some implications for its functional role