The determination of biperidin in plasma using gas chromatography mass spectrometry: Pharmacokinetics after intramuscular administration to guinea pigs

Biomedical Chromatography

Volumn 16, Issue 1, 2002, Pages 47-55

  Capacio, B R ^a   Caro, S T ^a   Smith, J R ^a   Byers, C E ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAS CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; PARAMETER ESTIMATION;

GASCHROMATOGRAPHY-MASS SPECTROMETRY; GUINEA PIGS; HEXANE EXTRACTION; INTRAMUSCULAR ADMINISTRATION; PARAMETERS ESTIMATES; PHARMACOKINETIC PARAMETERS; PLASMA CONCENTRATION; SEIZURE ACTIVITY; SIMPLE++; SPECTROMETRIC METHODS;

PHARMACOKINETICS;

BIPERIDEN; ORGANOPHOSPHATE; TRIHEXYPHENIDYL; ANTIPARKINSON AGENT;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; GAS CHROMATOGRAPHY; GUINEA PIG; LINEAR SYSTEM; MALE; MASS SPECTROMETRY; NONHUMAN; SEIZURE; SENSITIVITY ANALYSIS; STANDARD; ANIMAL; BLOOD; HALF LIFE TIME; INTRAMUSCULAR DRUG ADMINISTRATION; MASS FRAGMENTOGRAPHY; METHODOLOGY; REPRODUCIBILITY;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

ANIMALS; ANTIPARKINSON AGENTS; BIPERIDEN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GUINEA PIGS; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; MODELS, ANIMAL; REPRODUCIBILITY OF RESULTS;

EID: 0036007507     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.113     Document Type: Article

References (30)

1. Efficacy comparison of scopolamine and diazepam against soman-induced debilitation in guinea pigs
2. Efficacy of injectable anticholinergic drugs against soman-induced convulsive/subconvulsive activity
3. Antagonism of somaninduced convulsions by midazolam diazepam and scopolamine
4. Central active cholinolytics and their estimation by capillary zone electrophoresis
5. Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective
6. Anticonvulsant actions of anticholinergic drugs in soman poisoning
7. Iatrogenic parkinsonism: The efficacy of treatment with biperiden
8. Progress in medical defense against nerve agents
9. Sodium valproate and biperiden in neuroleptic-induced akathisia, parkinsonism and hyperkinesia. A double-blind cross-over study with placebo
10. Pharmacokinetic and pharmacodynamic studies following the intravenous and oral administration of the antiparkinsonian drug biperiden to normal subjects
11. Assay of biperiden in serum
12. Biperiden effects and plasma levels in volunteers
13. Capillary gas chromatographic determination of biperiden in human plasma
14. Pharmacological modulation of soman-induced seizures
15. Comparative evaluation of benzodiazepines for control of soman-induced seizures
16. Anticonvulsant treatment of nerve agent seizures: Anticholinergics versus diazepam in somanintoxicated guinea pigs
17. The clinical use of anticholinergic drugs as treatment for extrapyramidal side effects of neuroleptic drugs
18. Effects of fasting on biperiden pharmacokinetics in the rat
19. Determination of biperiden in human serum by glass capillary gas chromatography with isothermal splitless injection and nitrogen-sensitive detection
20. Anticonvulsants for poisoning by the organophosphorus compound soman: Pharmacological mechanisms
21. Effects of anticholinergic-antiparkinsonian drugs on striatal neurotransmitter levels of rats intoxicated with soman
22. Clinical considerations in nerve agent intoxication
23. Treatment of central nervous system degenerative disorders
24. A simple but highly sensitive radioreceptor assay for the determination of scopolamine and biperiden in human plasma
25. Anticholinesterase agents
26. Interaction study between remoxipride and biperiden
27. Simultaneous microdetermination of biperiden, haloperidol and trihexyphenidyl in plasma and its application to pharmacokinetic analysis after concomitant intravenous administration of the drugs to rabbits
28. Fundamental pharmacokinetic properties of biperiden: Tissue distribution and elimination in rabbits
29. Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats
30. Brain regional pharmacokinetics of biperiden in rats