An intramolecular silyl transfer from the carboxylate to the hydroxyl group in sodium 4-hydroxybutyrate and its application to the synthesis of injectable antifungal posaconazole derivative, Sch 59884

Organic Process Research and Development

Volumn 6, Issue 1, 2002, Pages 36-41

  Renton, P ^a   Shen, L ^a   Eckert, J ^a   Lee, G M ^a   Gala, D ^a   Chen, G ^a   Pramanik, B ^a   Schumacher, D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BUTYRIC ACID DERIVATIVE; CARBOXYLIC ACID; CHEMICAL COMPOUND; HYDROXYL GROUP; OXYBATE SODIUM; POSACONAZOLE; SCH 59884; SODIUM 4 HYDROXYBUTYRIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG RESEARCH; DRUG SYNTHESIS; INJECTION; MOLECULAR DYNAMICS;

EID: 0036003914     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op010230d     Document Type: Article

References (16)

1. Synthesis of injectable antifungal Sch 59884