A new solution-based intranasal triamcinolone acetonide formulation in patients with perennial allergic rhinitis: How does the pharmacokinetic/pharmacodynamic profile for cortisol suppression compare with an aqueous suspension-based formulation?

Journal of Clinical Pharmacology

Volumn 42, Issue 6, 2002, Pages 662-669

  Hochhaus, Günther ^a   González, Mario A ^b   Dockhorn, Robert J ^c   Shilstone, Jonathan ^d   Karafilidis, John ^d  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b Globomax Américas   (United States)

^c Intl Med Tech Consultants Inc   (United States)

^d Muro Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; TRI NASAL; TRIAMCINOLONE ACETONIDE;

ADULT; AQUEOUS SOLUTION; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; MALE; PERENNIAL RHINITIS; RANDOMIZED CONTROLLED TRIAL; AREA UNDER THE CURVE; BLOOD; COMPARATIVE STUDY; DRUG EFFECT; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTRANASAL DRUG ADMINISTRATION; SUSPENSION;

ADMINISTRATION, INTRANASAL; ADULT; AREA UNDER CURVE; COMPARATIVE STUDY; CROSS-OVER STUDIES; FEMALE; HUMAN; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; RHINITIS, ALLERGIC, PERENNIAL; SUSPENSIONS; TRIAMCINOLONE ACETONIDE; HUMANS;

EID: 0036000318     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00970002042006009     Document Type: Article

References (19)

1. Intranasal corticosteroids for allergic rhinitis: How do different agents compare?
2. Systemic effects of intranasal steroids: An endocrinologist's perspective
3. Radioimmunologische bestimmungen von triamcinoloacetonid und ihre anwendung in einer studie zur hydrolyse wasserloeslicher kortikoidester
4. Mathematical modeling of cortisol circadian rhythm and cortisol suppression
5. Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral and inhaled administration
6. A pharmacokinetic/pharmacodynamic approach to predict the cumulative cortisol suppression of inhaled corticosteroids
7. Systemic bioavailability of fluticasone propionate administered as nasal drops and aqueous nasal spray formulation
8. Nasal mucosal inflammation has no effect on the absorption of intranasal triamcinolone acetonide
9. Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration
10. Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism
11. The effects of triamcinolone acetonide aqueous nasal spray on adrenocortical function in children with allergic rhinitis
12. The efficacy of fluticasone propionate aqueous nasal spray for allergic rhinitis and its relationship to topical effects
13. Effects of repeated once daily dosing of three intranasal corticosteroids on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity
14. A five-way parallel randomized study to compare the safety profile of beclomethasone dipropionate, budesonide, flunisolide, fluticasone propionate, and triamcinolone acetonide in healthy male volunteers
15. Dose-response comparison of systemic bioactivity with inhaled budesonide and triamcinolone acetonide in asthmatic adults
16. Effects of high-dose inhaled corticosteroids on plasma cortisol concentrations in healthy adults
17. A study comparing the clinical pharmacokinetics, pharmacodynamics, and tolerability of triamcinolone acetonide HFA-134a metered-dose inhaler and budesonide dry-powder inhaler following inhalation