The excretion of cephem antibiotics into saliva is inversely associated with their plasma protein-binding activities

Journal of Oral Pathology and Medicine

Volumn 31, Issue 2, 2002, Pages 109-116

  Hamada, Toshihiro ^a   Ueta, Eisaku ^a   Kodama, Hiroyuki ^a   Osaki, Tokio ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Antibiotics; Excretion; Protein binding activity; Saliva

Indexed keywords

CEFOTAXIME; CEFOZOPRAN; CEFTIZOXIME; CEFUZONAM; CEPHALOSPORIN DERIVATIVE; DRUG DERIVATIVE; FLOMOXEF;

ADULT; ANIMAL; AREA UNDER THE CURVE; ARTICLE; BLOOD; DIFFUSION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; MALE; METABOLISM; NONPARAMETRIC TEST; PERFUSION; PH; PROTEIN BINDING; RAT; SALIVA; SPRAGUE DAWLEY RAT;

ADULT; ANIMALS; AREA UNDER CURVE; CEFOTAXIME; CEFTIZOXIME; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; KINETICS; MALE; PERFUSION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SALIVA; STATISTICS, NONPARAMETRIC;

EID: 0035999759     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0904-2512.2001.00015.x     Document Type: Article

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