Developmental toxicity of levo-alpha-acetylmethadol (LAAM) in tolerant rats

International Journal of Toxicology

Volumn 21, Issue 2, 2002, Pages 147-159

  York, Raymond G ^a   Denny, Kevin H ^a   Moody, David E ^b   Alburges, Mario E ^b  

^a International Research and Development Corporation   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Developmental Toxicity; LAAM (Levo alpha acetylmethadol); Tissue Concentrations

Indexed keywords

LEVACETYLMETHADOL; ACETYLMETHADOL; NARCOTIC ANALGESIC AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY BURDEN; BRAIN LEVEL; CESAREAN SECTION; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DRUG TOLERANCE; FEMALE; FETOTOXICITY; GESTATIONAL AGE; HAIR LOSS; LIVER LEVEL; MOTOR ACTIVITY; NONHUMAN; RAT; SKELETON MALFORMATION; TERATOGENICITY; ANIMAL; BODY WEIGHT; CONGENITAL MALFORMATION; DRUG EFFECT; EATING; EMBRYO DEVELOPMENT; MALE; NIDATION; ORAL DRUG ADMINISTRATION; PREGNANCY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANALGESICS, OPIOID; ANIMAL; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EATING; EMBRYO IMPLANTATION; FEMALE; MALE; METHADYL ACETATE; MOTOR ACTIVITY; POSTIMPLANTATION PHASE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, P.H.S.; TOXICITY TESTS; ANIMALS; EMBRYONIC DEVELOPMENT;

ANIMALIA;

EID: 0035999573     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/10915810252866105     Document Type: Article

References (32)

1. The effect of α-l-acetylmethadol hydrochloride on rat hepatic aryl hydrocarbon hydroxylase and epoxide hydrolase
2. The metabolism of drugs in isolated hepatocytes: A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions
3. Toxicological evaluation of μ-agonists. Part I: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-acetylmethadol HCl (LAAM)
4. Note on the staining of the skeleton of cleared specimens with Alizarin Red S
5. New tables for multiple comparisons with a control
6. Chemistry and pharmacology of the methadols and acetylmethadols
7. Levo-alpha-acetylmethadol (LAAM) for the treatment of opioid dependence: A multisite, open-label study of LAAM safety and an evaluation of the product labeling and treatment regulations
8. Stereotypy following acute administration of l-alpha-acetylmethadol (LAAM) in the rat
9. The binding of optical isomers of methadone, α-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain
10. Comparison of acetylmethadol and methadone in the treatment of long-term heroin users
11. The effects of thalidome on the fertility of rats studied in two generations
12. Levomethadyl acetate. Prolonged duration of opioid effects, including cross tolerance to heroin, in man
13. Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate
14. Outcome of pregnancy in rats chronically exposed to l-α-acetylmethadol (LAAM)
15. Congenital behavioral effects in mature rats prenatally exposed to levo-alpha-acetylmethadol (LAAM)
16. Prenatal levo-alpha-acetylmethadol (LAAM) and/or naloxone: Effects on brain chemistry and postweanling behavior
17. Methadyl acetate and methadone as maintenance treatments for heroin addicts
18. Comparative study of the electroencephalographic and behavioral effects of l-α-acetylmethadol (LAAM), two of its metabolites, and morphine and methadone in the rat
19. 3H]acetylmethadol and its metabolites in maternal and fetal rat tissue
20. Neuropharmacology and neurochemistry of subjective effects, analgesia, tolerance and dependence produced by narcotic analgesics
21. Microsomal enzyme induction following repeated oral administration of LAAM
22. Separation of hepatic N-demethylase-inducing and opioid dependence-producing doses of levo-alpha-acetylmethadol in the pregnant rat
23. The involvement of cytochrome P450 3A in the N-demethylation of l-α-acetylmethadol (LAAM), norLAAM and methadone
24. A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of l-α-acetylmethadol (LAAM), norLAAM, and dinorLAAM in plasma, urine, and tissue
25. Synthesis and identification of metabolites resulting from the biotransformation of dl-methadone in man and in the rat
26. In vivo carcinogenicity assay of 1-alpha-acetylmethadol HCl in rodents
27. Developmental effects of narcotics
28. Methods for administering agents and detecting malformations in experimental animals
29. "Apparent hydronephrosis" as a normal aspect of renal development in late gestation of rats