The role of cytokines in the epithelial cancer microenvironment

Seminars in Cancer Biology

Volumn 12, Issue 2, 2002, Pages 113-120

  Wilson, Julia ^a   Balkwill, Fran ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Chemokines; Cytokines; Epithelial cancer; Tumour microenvironment

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER GROWTH; CARCINOMA; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EPITHELIUM TUMOR; FIBROBLAST; GENETIC POLYMORPHISM; IMMUNE DEFICIENCY; LEUKOCYTE; METASTASIS; MICROENVIRONMENT; NONHUMAN; REVIEW; TUMOR CELL; ANIMAL; EPITHELIUM; EXTRACELLULAR SPACE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; VASCULARIZATION;

ANIMALS; CHEMOKINES; CYTOKINES; EPITHELIUM; EXTRACELLULAR SPACE; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035999153     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2001.0419     Document Type: Article

References (78)

1. Inflammation and cancer: Back to Virchow
2. A cytokine profile of normal and malignant ovary
3. Candidate genes for hypoxic tumor phenotype
4. Analysis of TNF-receptor and ligand superfamily molecules in patients with lymphoproliferative disease of granular lymphocytes
5. Dual role of tumor necrosis factor-a in angiogenesis
6. Clinical applications of TNF-a in cancer
7. Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
8. Tumor necrosis factor-a represses androgen sensitivity in the LNCaP prostate cell cancer line
9. Association between tumor necrosis factor in serum and cachexia in patients with prostate cancer
10. Elevated circulating levels of tumor necrosis factor predict unresponsiveness to treatment with interferon alfa-2b in chronic myelogenous leukemia
11. Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: A possible regulatory role of TNF in the progression of the disease
12. Tumor necrosis factor and its receptors in human ovarian cancer
13. Hypoxia down-regulates MCP-1 expression: Implications for macrophage distribution in tumors
14. Regulation of monocyte MMP-9 production by TNF-a and a tumour-derived soluble factor (MMPSF)
15. Paradoxical effects of tumour necrosis factor in experimental ovarian cancer
16. Cells secreting tumour necrosis factor show enhanced metastasis in nude mice
17. Cytokines in non-genotoxic hepatocarcinogenesis
18. Tumour necrosis factor-a deficient mice are resistant to skin carcinogenesis
19. Essential role of tumor necrosis factor a (TNF-a) in tumor promotion as revealed by TNF-a-deficient mice
20. Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline
21. Tumor necrosis factor-a enhanced tumorigenesis is associated with an angiogenic switch during tumor promotion
22. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
23. Interleukin 1-dependent and -independent mouse melanoma metastases
24. Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice
25. Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation
26. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
27. Nitric oxide synthase activity in human gynecological cancer
28. Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice
29. Induction of vascular endothelial growth factor by tumor necrosis factor a in human glioma cells
30. Tumor necrosis factor ligand-receptor system can predict treatment outcome in lymphoma patients
31. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome
32. Frequent genotype changes at -308 and 488 regions of the tumor necrosis factor-alpha (TNF-alpha) gene in patients with prostate cancer
33. High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment
34. Interleukin-1 polymorphisms associated with increased risk of gastric cancer
35. A polymorphism of the interleukin-1b gene influences survival in pancreatic cancer
36. A review of the influence of bacterial infection and bacterial products (Coley's toxins) on malignant tumors in man
37. An endotoxin-induced serum factor that causes necrosis of tumours
38. Human tumour xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons
39. Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells
40. The p55 TNF-a receptor plays a critical role in T cell alloreactivity
41. Tumour necrosis factor in man: Clinical and biological observations
42. High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma
43. High dose tumor necrosis factor-alpha (TNF), gamma-interferon (IFN) and melphalan in isolation perfusion of the limb in patients with irresectable soft tissue sarcomas
44. Chemokines: A new classification system and their role in immunity
45. Chemokines: Immunology's high impact factors
46. Chemokines and disease
47. Regulation of the macrophage content of neoplasms by chemoattractants
48. Human monocyte chemoattractant protein-1 (MCP-1)
49. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
50. Tumor-derived chemotactic factor(s) from human ovarian carcinoma: Evidence for a role in the regulation of macrophage content of neoplastic tissues
51. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFa and IL-1a
52. A quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of CC chemokines
53. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer
54. Epithelial cancer cell migration: A role for chemokine receptors?
55. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
56. Macrophage inflammatory protein 3a transgene attracts dendritic cells to established murine tumors and suppresses tumor growth
57. The CC chemokine CKb-11/MIP-3b/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells
58. Antitumor effects of the mouse chemokine 6CKine/SLC through angiostatic and immunological mechanisms
59. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo
60. CXC chemokines in angiogenesis
61. Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer
62. Interferon-g-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases
63. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice
64. The role of Mig, the monokine induced by interferon-gamma, and IP-10, the interferon-gamma-inducible protein-10, in tissue necrosis and vascular damage associated with Epstein-Barr virus-positive lymphoproliferative disease
65. The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model
66. Mechanism and biological significance on constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression
67. Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1
68. Detection and localization of MIP-3a/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer
69. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma
70. Interleukiu 8: An autocrine growth factor for human ovarian cancer
71. Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells
72. Blockade of nuclear factor-kB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
73. IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration
74. Involvement of chemokine receptors in breast cancer metastasis
75. Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression
76. Identification and localization of the cytokine SDF1 and its receptor. CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
77. Infliximab and methotrexate in the treatment of rheumatoid arthritis
78. Antibodies to tumour necrosis factor as a treatment for Crohn's disease