Solution equilibria of deferoxamine amides

Journal of Pharmaceutical Sciences

Volumn 91, Issue 7, 2002, Pages 1733-1741

  Ihnat, Peter M ^a   Vennerstrom, Jonathan L ^a   Robinson, Dennis H ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Analogs; Deferoxamine; Ionization constants; Lipophilicity; Stability constant

Indexed keywords

DEFEROXAMINE; DEFEROXAMINE AMIDE; EDETIC ACID; UNCLASSIFIED DRUG; AMIDE; DRUG DERIVATIVE; ION;

ACYLATION; ARTICLE; BINDING AFFINITY; DISSOCIATION; DRUG CONFORMATION; DRUG SOLUBILITY; IONIZATION; IRON KINETICS; IRON METABOLISM; LIPOPHILICITY; NONLINEAR SYSTEM; PHYSICAL CHEMISTRY; POTENTIOMETRY; PROTON TRANSPORT; REGRESSION ANALYSIS; SOLVATION; STATISTICAL ANALYSIS; STEREOSPECIFICITY; CHEMISTRY; DRUG STABILITY; SOLUTION AND SOLUBILITY;

AMIDES; DEFEROXAMINE; DRUG STABILITY; IONS; PHARMACEUTICAL SOLUTIONS;

EID: 0035998960     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10168     Document Type: Article

References (26)

1. Deferoxamine pharmacokinetics
2. The biochemistry of desferrioxamine and its relation to iron metabolism
3. Evidence that desferrioxamine cannot enter cells by passive diffusion
4. Iron chelation: New therapies
5. Synthesis and solution properties of deferoxamine amides
6. The design and synthesis of chelating agents
7. 1H NMR study of four desferrioxamine B derivatives and their ferric complexes
8. Iron bioavailability and the coordination chemistry of hydroxamic acids
9. Complexation of iron by siderophores: A review of their solution and structural chemistry and biological function
10. Hydroxamatkomplexe III: Eisen(III)-austausch zwischen sideraminen und komplexonen
11. Solution thermodynamics of the ferric complexes of new desferrioxamine siderophores obtained by directed fermentation
12. Prodrugs of amides, imides and amines
13. Potentiometric determination of the thermodynamic ionization constants of deferoxamine
14. Potentiometric determination of thermodynamic and apparent dissociation constants by nonlinear least squares fitting
15. Kinetics and mechanism of the stepwise dissociation of iron (III) from ferrioxamine B in aqueous acid
16. The chemistry of hydroxamic acids and N-hydroxyimides
17. Oxygen-17 NMR studies of the structures of benzohydroxamic acids and benzohydroxamate ions in solution
18. A thermodynamic description of the binding of iron to ferrioxamine B in aqueous solution
19. Acid dissociation constants and their temperature dependencies for a series of carbon and nitrogen substituted hydroxamic acids in aqueous solution
20. Acidity of hydroxamic acids: An ab initio and semiempirical study
21. The structure of ferrioxamine D-ethanol-water (1/2/1)
22. Coordination chemistry of microbial iron transport compounds 21: Kinetics and mechanism of iron exchange in hydroxamate siderophore complexes
23. Hydroxamatkomplexe I: Die stabilitat der eisen (III)-komplexe einfacher hydroxamsauren und des ferrioxamins B