Minor form of trigonocephaly is an autistic skull shape? A suggestion based on homeobox gene variants and MECP2 mutations

Medical Hypotheses

Volumn 58, Issue 4, 2002, Pages 337-339

  Ijichi, S ^a   Ijichi, N ^a  

^a Institute for EGT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR MECP2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HOMEOBOX A1 PROTEIN; HOMEODOMAIN PROTEIN; MECP2 PROTEIN, HUMAN; METHYL CPG BINDING PROTEIN 2; NONHISTONE PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MSX2;

ARTICLE; AUTISM; BEHAVIOR DISORDER; BRAIN DEVELOPMENT; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ETHICS; GENE; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HEAD; HOMEOBOX; HOXA1 GENE; HUMAN; HYPERACTIVITY; HYPOTHESIS; MECP2 GENE; PRIORITY JOURNAL; RETT SYNDROME; SKULL DEFECT; SKULL DEVELOPMENT; SKULL SURGERY; TRIGONOCEPHALY; ATTENTION DEFICIT DISORDER; CRANIOFACIAL SYNOSTOSIS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; INFANT; MALE; MORPHOGENESIS; MUTATION; NEWBORN; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; PSYCHOLOGICAL ASPECT; SKULL; X CHROMOSOME;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTISTIC DISORDER; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, HUMAN, X; CRANIOSYNOSTOSES; DNA METHYLATION; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENETIC PREDISPOSITION TO DISEASE; HOMEODOMAIN PROTEINS; HUMANS; INFANT; INFANT, NEWBORN; MALE; METHYL-CPG-BINDING PROTEIN 2; MORPHOGENESIS; MUTATION; PHENOTYPE; REPRESSOR PROTEINS; RETT SYNDROME; SKULL; TRANSCRIPTION FACTORS;

EID: 0035996670     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2001.1528     Document Type: Article

References (18)

1. The genetic basis of complex human behaviors
2. Association study with two markers of a human homeogene in infantile autism
3. Discovery of allelic variants of HOXA1 and HOXB1: Genetic susceptibility to autism spectrum disorders
4. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
5. Craniofacial disorders caused by mutations in homeobox genes MSX1 and MSX2
6. Otx and Emx homeobox genes in brain development
7. Multiple functions of D1x genes
8. Molecular genetics of craniosynostotic syndromes
9. Head circumference is an independent clinical finding associated with autism
10. Rett syndrome model suggests MECP2 gives neurons the quiet they need to think
11. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
12. Rett syndrome and beyond: Recurrent spontaneous and familial MECP2 mutations at CpG hotspots
13. Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein
14. Somatic mutation in MECP2 as a non-fatal neurodevelopmental disorder in males
15. Trigonocephaly associated with symptoms: Mainly nonsyndromic type
16. Trigonocephaly associated with symptoms: Indication of surgical treatment
17. Consensus: Trigonocephaly